Idelevich, E. A., Seifert, H., Sundqvist, M., Scudeller, L., Amit, S., Balode, A., Bilozor, A., Drevinek, P., Tufan, Z. Kocak, Koraqi, A., Lamy, B., Marekovic, I., Miciuleviciene, J., Premru, M. Mueller, Pascual, A., Pournaras, S., Saegeman, V., Schonheyder, H. C., Schrenzel, J., Strateva, T., Tilley, R., Wiersinga, W. J., Zabicka, D., Carmeli, Y. and Becker, K. (2019). Microbiological diagnostics of bloodstream infections in Europe-an ESGBIES survey. Clin. Microbiol. Infect., 25 (11). S. 1399 - 1408. OXFORD: ELSEVIER SCI LTD. ISSN 1469-0691

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Abstract

Objectives: High-quality diagnosis of bloodstream infections (BSI) is important for successful patient management. As knowledge on current practices of microbiological BSI diagnostics is limited, this project aimed to assess its current state in European microbiological laboratories. Methods: We performed an online questionnaire-based cross-sectional survey comprising 34 questions on practices of microbiological BSI diagnostics. The ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis (ESGBIES) was the primary platform to engage national coordinators who recruited laboratories within their countries. Results: Responses were received from 209 laboratories in 25 European countries. Although 32.5% (68/209) of laboratories only used the classical processing of positive blood cultures (BC), two-thirds applied rapid technologies. Of laboratories that provided data, 42.2% (78/185) were able to start incubating BC in automated BC incubators around-the-clock, and only 13% (25/192) had established a 24-h service to start immediate processing of positive BC. Only 4.7% (9/190) of laboratories validated and transmitted the results of identification and antimicrobial susceptibility testing (AST) of BC pathogens to clinicians 24 h/day. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry from briefly incubated sub-cultures on solid media was the most commonly used approach to rapid pathogen identification from positive BC, and direct disc diffusion was the most common rapid AST method from positive BC. Conclusions: Laboratories have started to implement novel technologies for rapid identification and AST for positive BC. However, progress is severely compromised by limited operating hours such that current practice of BC diagnostics in Europe complies only partly with the requirements for optimal BSI management. (C) 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Idelevich, E. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sundqvist, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scudeller, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amit, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balode, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilozor, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drevinek, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tufan, Z. KocakUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koraqi, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamy, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marekovic, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miciuleviciene, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Premru, M. MuellerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pascual, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pournaras, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saegeman, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonheyder, H. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrenzel, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strateva, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tilley, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiersinga, W. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zabicka, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carmeli, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-129625
DOI: 10.1016/j.cmi.2019.03.024
Journal or Publication Title: Clin. Microbiol. Infect.
Volume: 25
Number: 11
Page Range: S. 1399 - 1408
Date: 2019
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1469-0691
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RAPID IDENTIFICATION; CULTURES; GUIDELINES; MANAGEMENT; INCUBATIONMultiple languages
Infectious Diseases; MicrobiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12962

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