Universität zu Köln

Hatamie, Shadie, Ahadian, Mohammad Mahdi ORCID: 0000-0002-5693-9848, Zomorod, Mahsa Soufi, Torabi, Shukoofeh, Babaie, Ali, Hosseinzadeh, Simzar, Soleimani, Masoud, Hatami, Niloofar and Wei, Zung-Hang (2019). Antibacterial properties of nanoporous graphene oxide/cobalt metal organic framework. Mater. Sci. Eng. C-Mater. Biol. Appl., 104. AMSTERDAM: ELSEVIER. ISSN 1873-0191

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Abstract

Metal-organic framework (MOF) based graphene oxide (GO) recently merits of attention because of the relative correspondence of GO with metal ions and organic binding linkers. Furthermore, introducing the GO to the Co-MOF to make a new nanoporous hybrid have are improved the selectivity and stability of the Co-MOF. Here the graphene oxide/cobalt metal organic framework (GO/Co-MOF) was synthesized by a solvothermal process using cobalt salt and terephthalic acid and used for biocidal activity, against the growth of the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria. X-ray diffraction, Fourier transform infrared spectroscopy and Raman spectroscopy were confirmed the successful synthesize of metal organic framework and incorporation of Co-MOF in to GO sheets. Scanning electron microscopy was showed the cornflower structure of GO/Co-MOF, and transmission electron microscopy was confirmed, the Co-MOF are decorated on GO. Cytotoxicity study of GO/Co-MOF using 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT) cell viability assay showed the biocompatibility to human fibroblasts cell over 72 h. The growth inhibition of the Escherichia coli and Staphylococcus aureus bacteria are reached over 99% for bacteria concentration of 100 mu g/mL. The excellent antibacterial activity of GO based Co-MOF is linked to synergistic effect of sharp edges of the GO sheets and the toxic effect of cobalt ions (Co2+) which are released from their surfaces. The GO/Co-MOF radical scavenging assay was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) antioxidant assay for samples incubated with cells which confirmed the minimum radicals' toxicity on bacteria. This novel graphene oxide based MOF with its intrinsic superior porous structure, highly active metal coordination, and commercial linker, is an excellent promising candidate to use in biological and pharmaceutical applications as high potential sustained bactericidal materials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hatamie, Shadie UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahadian, Mohammad Mahdi UNSPECIFIED orcid.org/0000-0002-5693-9848 UNSPECIFIED Zomorod, Mahsa Soufi UNSPECIFIED UNSPECIFIED UNSPECIFIED Torabi, Shukoofeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Babaie, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Hosseinzadeh, Simzar UNSPECIFIED UNSPECIFIED UNSPECIFIED Soleimani, Masoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Hatami, Niloofar UNSPECIFIED UNSPECIFIED UNSPECIFIED Wei, Zung-Hang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130018
DOI:	10.1016/j.msec.2019.109862
Journal or Publication Title:	Mater. Sci. Eng. C-Mater. Biol. Appl.
Volume:	104
Date:	2019
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-0191
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESCHERICHIA-COLI; AT-GO; OXIDE; MEMBRANE; LABEL; MOF Multiple languages Materials Science, Biomaterials Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13001