Universität zu Köln

Koelkebeck, Katja, Dannlowski, Udo, Ohrmann, Patricia, Suslow, Thomas, Murai, Toshiya, Bauer, Jochen, Pedersen, Anya, Matsukawa, Noriko, Son, Shuraku, Haidl, Theresa and Miyata, Jun (2019). Gray matter volume reductions in patients with schizophrenia: A replication study across two cultural backgrounds. Psychiatry Res. Neuroimaging, 292. S. 32 - 41. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7506

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Abstract

Structural gray matter (GM) volume reductions in patients with schizophrenia have rarely been replicated across two different sites, the impact of culture and clinical characteristics remains unresolved. Hence, we assessed GM volume reductions in patients with schizophrenia using 3 T magnetic resonace imaging to replicate results across two independent and culturally different backgrounds (Germany, Japan), and to investigate the impact of brain volume reductions on clinical characteristics. In total, 163 German (80 patients) and 203 Japanese (83 patients) participants were included in the analysis. Voxel-based morphometry (VBM) was used to investigate structural differences between the groups and across the two sites, comparing local GM volumes. Clinical variables were used to analyze effects unrelated to the socio-cultural background. Across both data sets, widespread GM reductions in frontal and temporal cortical parts were found between patients and controls, indicating strong effects of diagnosis and only small effects of site. The investigation of clinical characteristics revealed the strongest effects for chlorpromazine equivalents on GM volume reductions primarily in the Japanese sample. Although the effects of site are small, several brain regions do not overlap between the two groups. Thus, GM may be affected differently at the two sites in patients with schizophrenia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koelkebeck, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Dannlowski, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Ohrmann, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Suslow, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Murai, Toshiya UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedersen, Anya UNSPECIFIED UNSPECIFIED UNSPECIFIED Matsukawa, Noriko UNSPECIFIED UNSPECIFIED UNSPECIFIED Son, Shuraku UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Miyata, Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130169
DOI:	10.1016/j.pscychresns.2019.08.008
Journal or Publication Title:	Psychiatry Res. Neuroimaging
Volume:	292
Page Range:	S. 32 - 41
Date:	2019
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7506
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOCIAL COGNITION; WHITE-MATTER; ANTIPSYCHOTIC TREATMENT; 1ST-EPISODE PSYCHOSIS; CORTICAL THICKNESS; BRAIN VOLUMES; ABNORMALITIES; DISORDER; RISK; METAANALYSIS Multiple languages Clinical Neurology; Neuroimaging; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13016