Zhou, Yifei ORCID: 0000-0003-0088-6262, Wang, Xueqing, Song, Mengjiao, He, Zhidong, Cui, Guizhong ORCID: 0000-0001-6394-2773, Peng, Guangdun ORCID: 0000-0002-8586-0637, Dieterich, Christoph, Antebi, Adam, Jing, Naihe ORCID: 0000-0003-1509-6378 and Shen, Yidong (2019). A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. Although tissue-specific changes in autophagy and ageing have been extensively explored, the mechanism underlying the inter-tissue regulation of autophagy with ageing is poorly understood. Here, we show that a secreted microRNA, mir-83/miR-29, controls the age-related decrease in macroautophagy across tissues in Caenorhabditis elegans. Upregulated in the intestine by hsf-1/HSF1 with age, mir-83 is transported across tissues potentially via extracellular vesicles and disrupts macroautophagy by suppressing CUP-5/MCOLN, a vital autophagy regulator, autonomously in the intestine as well as non-autonomously in body wall muscle. Mutating mir-83 thereby enhances macroautophagy in different tissues, promoting protein homeostasis and longevity. These findings thus identify a microRNA-based mechanism to coordinate the decreasing macroautophagy in various tissues with age.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zhou, YifeiUNSPECIFIEDorcid.org/0000-0003-0088-6262UNSPECIFIED
Wang, XueqingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Song, MengjiaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
He, ZhidongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cui, GuizhongUNSPECIFIEDorcid.org/0000-0001-6394-2773UNSPECIFIED
Peng, GuangdunUNSPECIFIEDorcid.org/0000-0002-8586-0637UNSPECIFIED
Dieterich, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antebi, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jing, NaiheUNSPECIFIEDorcid.org/0000-0003-1509-6378UNSPECIFIED
Shen, YidongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-130546
DOI: 10.1038/s41467-019-12821-2
Journal or Publication Title: Nat. Commun.
Volume: 10
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEAT-SHOCK RESPONSE; EXTRACELLULAR VESICLES; GENE-EXPRESSION; LIFE-SPAN; STRESS; PROTEOSTASIS; PATHWAYS; PROFILE; GROWTHMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13054

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