Universität zu Köln

Tscherpel, Caroline, Hensel, Lukas, Lemberg, Katharina, Freytag, Jana, Michely, Jochen, Volz, Lukas J. ORCID: 0000-0002-0161-654X, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian ORCID: 0000-0002-1656-720X (2020). Age affects the contribution of ipsilateral brain regions to movement kinematics. Hum. Brain Mapp., 41 (3). S. 640 - 656. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Healthy aging is accompanied by changes in brain activation patterns in the motor system. In older subjects, unilateral hand movements typically rely on increased recruitment of ipsilateral frontoparietal areas. While the two central concepts of aging-related brain activity changes, Hemispheric Asymmetry Reduction in Older Adults (HAROLD), and Posterior to Anterior Shift in Aging (PASA), have initially been suggested in the context of cognitive tasks and were attributed to compensation, current knowledge regarding the functional significance of increased motor system activity remains scarce. We, therefore, used online interference transcranial magnetic stimulation in young and older subjects to investigate the role of key regions of the ipsilateral frontoparietal cortex, that is, (a) primary motor cortex (M1), (b) dorsal premotor cortex (dPMC), and (c) anterior intraparietal sulcus (IPS) in the control of hand movements of different motor demands. Our data suggest a change of the functional roles of ipsilateral brain areas in healthy age with a reduced relevance of ipsilateral M1 and a shift of importance toward dPMC for repetitive high-frequency movements. These results support the notion that mechanisms conceptualized in the models of PASA and HAROLD also apply to the motor system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Hensel, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemberg, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Freytag, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Michely, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130829
DOI:	10.1002/hbm.24829
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	41
Number:	3
Page Range:	S. 640 - 656
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; DORSAL PREMOTOR CORTEX; INTERHEMISPHERIC INHIBITION; CORTICAL EXCITABILITY; NETWORK CONNECTIVITY; FINGER MOVEMENTS; CALLOSAL CONNECTIONS; BIMANUAL MOVEMENTS; VENTRAL PREMOTOR Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13082