Universität zu Köln

Mueller, Hendrik, Kommescher, Mareike, Guettgemanns, Joern, Wessels, Helen, Walger, Petra, Lehmkuhl, Gerd, Kuhr, Kathrin, Hamacher, Stefanie ORCID: 0000-0003-2158-9101, Lehmacher, Walter, Mueller, Kerstin, Herrlich, Jutta, Wiedemann, Georg, Stoesser, Dieter, Klingberg, Stefan and Bechdolf, Andreas (2020). Cognitive behavioral therapy in adolescents with early-onset psychosis: a randomized controlled pilot study. Eur. Child Adolesc. Psych., 29 (7). S. 1011 - 1023. NEW YORK: SPRINGER. ISSN 1435-165X

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Abstract

Cognitive behavioral therapy for psychosis (CBT) is an effective treatment in adult patients with schizophrenia. However, no randomized controlled and blinded trial in adolescents with early-onset psychosis (EOP) has been conducted. Therefore, the present pilot study explores the acceptance, tolerability, feasibility, and safety of a modified CBT in adolescents with EOP. Twenty-five adolescents with EOP were randomized to either 9 months (20 sessions) of CBT + treatment as usual (TAU) or TAU alone. The primary endpoint was the PANSS-positive subscale (P1-7). Secondary endpoints included psychopathology, global functioning, and quality of life (QoL). Acceptance, tolerability, feasibility, and safety were assessed. Blinded assessments took place by the end of the treatment (9 months) and at 24-month follow-up. Despite improvements in both groups and lack of statistical significance between CBT + TAU and TAU regarding the primary endpoint, we observed between-group effect sizes of at leastd = 0.39 in favor of CBT + TAU at post-treatment for delusions, negative symptoms, functioning and QoL after the intervention and effect sizes of at leastd = 0.35 after 24 months. CBT in EOP was highly acceptable (73.5% agreed to randomization), well-tolerated (83.1% attendance rate, no drop-outs), and safe (one serious adverse event (SAE) in CBT + TAU in comparison with six SAEs in TAU). These findings suggest that CBT adapted to the needs of adolescents with EOP is a promising approach regarding negative symptoms, functioning, and QoL. CBT is a safe and tolerable treatment. However, due to the small sample size and the pilot character of the study, these conclusions are limited, and should be tested in a larger, adequately powered randomized controlled trial.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Kommescher, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Guettgemanns, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Wessels, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Walger, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmkuhl, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhr, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, Stefanie UNSPECIFIED orcid.org/0000-0003-2158-9101 UNSPECIFIED Lehmacher, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrlich, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiedemann, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoesser, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131070
DOI:	10.1007/s00787-019-01415-4
Journal or Publication Title:	Eur. Child Adolesc. Psych.
Volume:	29
Number:	7
Page Range:	S. 1011 - 1023
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-165X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; CONTROLLED-TRIAL; EARLY SCHIZOPHRENIA; ACUTE-PHASE; FOLLOW-UP; 1ST-EPISODE; HALLUCINATIONS; METAANALYSIS; RATIONALE; DELUSIONS Multiple languages Psychology, Developmental; Pediatrics; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13107