Feng, Chen, Chan, Wilson Cheuk Wing, Lam, Yan, Wang, Xue, Chen, Peikai, Niu, Ben, Ng, Vivian Chor Wing, Yeo, Jia Chi, Stricker, Sigmar, Cheah, Kathryn Song Eng, Koch, Manuel, Mundlos, Stefan, Ng, Huck Hui and Chan, Danny (2019). Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes. Stem Cell Rep., 13 (4). S. 713 - 730. CAMBRIDGE: CELL PRESS. ISSN 2213-6711

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Abstract

The synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor cells. However, lineage specification and progression toward the different tissues of the joint are not well understood. Here, by lineage-tracing studies we identify a population of Lgr5(+) interzone cells that contribute to the formation of cruciate ligaments, synovial membrane, and articular chondrocytes of the joint. This finding is supported by single-cell transcriptome analyses. We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5(+ )cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes. Lgr5(+) cells contribute to the repair of a joint defect with the re-establishment of a Col22a1-expressing superficial layer.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Feng, ChenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, Wilson Cheuk WingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lam, YanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, XueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, PeikaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niu, BenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ng, Vivian Chor WingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeo, Jia ChiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stricker, SigmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheah, Kathryn Song EngUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mundlos, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ng, Huck HuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, DannyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-131257
DOI: 10.1016/j.stemcr.2019.08.006
Journal or Publication Title: Stem Cell Rep.
Volume: 13
Number: 4
Page Range: S. 713 - 730
Date: 2019
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 2213-6711
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYNOVIAL JOINT; CARTILAGE FORMATION; EXPRESSION; MORPHOGENESIS; IDENTIFICATION; PATTERNMultiple languages
Cell & Tissue Engineering; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13125

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