Universität zu Köln

Dembek, T. A., Hoevels, M., Hellerbach, A., Horn, A., Petry-Schmelzer, J. N., Borggrefe, J., Wirths, J., Dafsari, H. S., Barbe, M. T., Visser-Vandewalle, V. and Treuer, H. (2019). Directional DBS leads show large deviations from their intended implantation orientation. Parkinsonism Relat. Disord., 67. S. 117 - 122. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Objective: Lead orientation is a new degree of freedom with directional deep brain stimulation (DBS) leads. We investigated how prevalent deviations from the intended implantation direction are in a large patient cohort. Methods: The Directional Orientation Detection (DiODe) algorithm to determine lead orientation from postoperative CT scans was implemented into the open-source Lead-DBS toolbox. Lead orientation was analyzed in 100 consecutive patients (198 leads). Different anatomical targets and intraoperative setups were compared. Results: Deviations of up to 90 degrees from the intended implantation direction were observed. Deviations of more than 30 degrees were seen in 42% of the leads and deviations of more than 60 degrees in about 11% of the leads. Deviations were independent from the neuroanatomical target and the stereotactic frame but increased depending on which microdrive was used. Discussion: Our results indicate that large deviations from the intended implantation direction are a common phenomenon in directional leads. Postoperative determination of lead orientation is thus mandatory for investigating directional DBS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dembek, T. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoevels, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellerbach, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, J. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirths, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, H. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, M. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treuer, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131774
DOI:	10.1016/j.parkreldis.2019.08.017
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	67
Page Range:	S. 117 - 122
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13177