Universität zu Köln

Goncharova, Olga, Flinner, Nadine, Bein, Julia, Doering, Claudia, Donnadieu, Emmanuel, Rikirsch, Sandy, Herling, Marco, Kueppers, Ralf, Hansmann, Martin-Leo and Hartmann, Sylvia (2019). Migration Properties Distinguish Tumor Cells of Classical Hodgkin Lymphoma from Anaplastic Large Cell Lymphoma Cells. Cancers, 11 (10). BASEL: MDPI. ISSN 2072-6694

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Abstract

Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advanced stage, cHL more frequently presents with localized disease. The aim of the present study was to elucidate the mechanisms underlying the different clinical presentation of ALCL and cHL. Chemokine and chemokine receptor expression were similar in primary ALCL and cHL cases apart from the known overexpression of the chemokines CCL17 and CCL22 in the Hodgkin and Reed-Sternberg (HRS) cells of cHL. Consistent with the overexpression of these chemokines, primary cHL cases encountered a significantly denser T cell microenvironment than ALCL. Additionally to differences in the interaction with their microenvironment, cHL cell lines presented a lower and less efficient intrinsic cell motility than ALCL cell lines, as assessed by time-lapse microscopy in a collagen gel and transwell migration assays. We thus propose that the combination of impaired basal cell motility and differences in the interaction with the microenvironment hamper the dissemination of HRS cells in cHL when compared with the tumor cells of ALCL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goncharova, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Flinner, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Bein, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Doering, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Donnadieu, Emmanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rikirsch, Sandy UNSPECIFIED UNSPECIFIED UNSPECIFIED Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Kueppers, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansmann, Martin-Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Sylvia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131782
DOI:	10.3390/cancers11101484
Journal or Publication Title:	Cancers
Volume:	11
Number:	10
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REED-STERNBERG CELLS; DIFFERENTIAL CHEMOKINE EXPRESSION; T-CELL; CC-CHEMOKINE; GENE REARRANGEMENTS; NPM-ALK; DISEASE; IDENTIFICATION; RECEPTORS; MOLECULES Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13178