Universität zu Köln

Lehmann, Sabrina, Thomas, Andreas, Schiwy-Bochat, Karl-Heinz, Geyer, Hans, Thevis, Mario, Glenewinkel, Frank, Rothschild, Markus Alexander, Andresen-Streichert, Hilke and Juebner, Martin (2019). Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone). Forensic Sci.Int., 303. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-6283

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Abstract

A 34-year old male was found breathless and panting at home by his girlfriend three hours after a gym workout. Minutes later, he collapsed and died. Autopsy, histological and chemical analyses were conducted. The examination of the heart showed left ventricular hypertrophy, while the right coronary artery showed only a small vascular lumen (3 mm in diameter), due to its anatomical structure. In femoral blood concentrations of approx. 1 mu g/L clenbuterol, approx. 56 mu g/L stanozolol and approx. 8 mg/L metandienone, with trenbolone (<limit of quantification (LOQ)) were detected. Additionally, there were positive results in urine for boldenone, clomiphene, trenbolone, metandienone, stanozolol, clenbuterol and drostanolone, along with indications of testosterone and/or testosterone prohormones having been taken. In consideration of all aspects of this case, in can be assumed that the long-term consumption of anabolic androgen steroids (AAS) caused apparently pathological changes of the heart. Over and above, the combination of anatomical (small lumed coronary artery, ventricular hypertrophy) and substance-induced risk factors led to the fatal cardiovascular failure. (C) 2019 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lehmann, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiwy-Bochat, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Glenewinkel, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothschild, Markus Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Andresen-Streichert, Hilke UNSPECIFIED UNSPECIFIED UNSPECIFIED Juebner, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131908
DOI:	10.1016/j.forsciint.2019.109925
Journal or Publication Title:	Forensic Sci.Int.
Volume:	303
Date:	2019
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-6283
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGENIC STEROIDS; DOPING AGENTS; CARDIAC DEATH; ABUSE; TACHYCARDIA; PLASMA; BLOOD Multiple languages Medicine, Legal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13190