Universität zu Köln

Huebl, Kai, Re, Alessandro ORCID: 0000-0003-1156-6395, Boumendil, Ariane, Finel, Herve, Hentrich, Marcus, Robinson, Stephen, Wyen, Christoph, Michieli, Mariagrazia ORCID: 0000-0001-6302-0488, Kanfer, Edward, Diez-Martin, Jose Luis ORCID: 0000-0003-1869-0129, Balsalobre, Pascual, Vincent, Laure, Schroyens, Wilfried, Ribera Santasusana, Josep Maria, Kroeger, Nicolaus, Schiel, Xaver, Cwynarski, Kate, Esquirol, Albert, Sousa, Aida Botelho, Cattaneo, Chiara, Montoto, Silvia and Dreger, Peter (2019). Autologous stem cell transplantation for HIV-associated lymphoma in the antiretroviral and rituximab era: a retrospective study by the EBMT Lymphoma Working Party. Bone Marrow Transplant., 54 (10). S. 1625 - 1632. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with lymphoma who received autoHCT between 2007 and 2013. A total of 118 patients were included with a median age of 45 years (range 24-66). Underlying diagnoses were diffuse large B cell lymphoma in 47%, Hodgkin lymphoma in 24%, Burkitt lymphoma in 18%, and plasmablastic lymphoma in 7% of patients. Disease status at autoHCT was complete remission in 44%, partial remission (PR) in 38%, and less than PR in 18% of the patients. With a median follow-up of 4 years, 3-year non-relapse mortality, incidence of relapse, progression-free survival (PFS) and overall survival (OS) were 10%, 27%, 63% and 66%, respectively. By multivariate analysis, disease status less than PR but not CD4+ cell count at the time of autoHCT was a significant predictor of unfavorable PFS and OS. In conclusion, in the era of cART and chemoimmunotherapy, the outcome of autoHCT for HIV-related lymphoma is driven by lymphoma-dependent risk factors rather than by characteristics of the HIV infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huebl, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Re, Alessandro UNSPECIFIED orcid.org/0000-0003-1156-6395 UNSPECIFIED Boumendil, Ariane UNSPECIFIED UNSPECIFIED UNSPECIFIED Finel, Herve UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Robinson, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wyen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Michieli, Mariagrazia UNSPECIFIED orcid.org/0000-0001-6302-0488 UNSPECIFIED Kanfer, Edward UNSPECIFIED UNSPECIFIED UNSPECIFIED Diez-Martin, Jose Luis UNSPECIFIED orcid.org/0000-0003-1869-0129 UNSPECIFIED Balsalobre, Pascual UNSPECIFIED UNSPECIFIED UNSPECIFIED Vincent, Laure UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroyens, Wilfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribera Santasusana, Josep Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiel, Xaver UNSPECIFIED UNSPECIFIED UNSPECIFIED Cwynarski, Kate UNSPECIFIED UNSPECIFIED UNSPECIFIED Esquirol, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Sousa, Aida Botelho UNSPECIFIED UNSPECIFIED UNSPECIFIED Cattaneo, Chiara UNSPECIFIED UNSPECIFIED UNSPECIFIED Montoto, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132824
DOI:	10.1038/s41409-019-0480-x
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	54
Number:	10
Page Range:	S. 1625 - 1632
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-DOSE THERAPY; CLINICAL-PRACTICE GUIDELINES; NON-HODGKIN-LYMPHOMA; PLASMABLASTIC LYMPHOMA; IMMUNODEFICIENCY; RISK; DIAGNOSIS; SURVIVAL; BLOOD Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13282