Universität zu Köln

Rive, Corvin, Reina, Giacomo ORCID: 0000-0002-8147-3162, Wagle, Prerana, Treossi, Emanuele, Palermo, Vincenzo, Bianco, Alberto, Gemma-Delogu, Lucia, Rieckher, Matthias ORCID: 0000-0002-1945-9474 and Schumacher, Bjoern (2019). Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Small, 15 (45). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1613-6829

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Abstract

Graphene oxide (GO) holds high promise for diagnostic and therapeutic applications in nanomedicine but reportedly displays immunotoxicity, underlining the need for developing functionalized GO with improved biocompatibility. This study describes adverse effects of GO and amino-functionalized GO (GONH(2)) during Caenorhabditis elegans development and ageing upon acute or chronic exposure. Chronic GO treatment throughout the C. elegans development causes decreased fecundity and a reduction of animal size, while acute treatment does not lead to any measurable physiological decline. However, RNA-Sequencing data reveal that acute GO exposure induces innate immune gene expression. The p38 MAP kinase, PMK-1, which is a well-established master regulator of innate immunity, protects C. elegans from chronic GO toxicity, as pmk-1 mutants show reduced tissue-functionality and facultative vivipary. In a direct comparison, GONH(2) exposure does not cause detrimental effects in the wild type or in pmk-1 mutants, and the innate immune response is considerably less pronounced. This work establishes enhanced biocompatibility of amino-functionalized GO in a whole-organism, emphasizing its potential as a biomedical nanomaterial.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rive, Corvin UNSPECIFIED UNSPECIFIED UNSPECIFIED Reina, Giacomo UNSPECIFIED orcid.org/0000-0002-8147-3162 UNSPECIFIED Wagle, Prerana UNSPECIFIED UNSPECIFIED UNSPECIFIED Treossi, Emanuele UNSPECIFIED UNSPECIFIED UNSPECIFIED Palermo, Vincenzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Bianco, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Gemma-Delogu, Lucia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieckher, Matthias UNSPECIFIED orcid.org/0000-0002-1945-9474 UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133013
DOI:	10.1002/smll.201902699
Journal or Publication Title:	Small
Volume:	15
Number:	45
Date:	2019
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1613-6829
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE-SPAN; GERM-LINE; IN-VIVO; REPRODUCTIVE TOXICITY; INTESTINAL BARRIER; IMMUNE-RESPONSE; STRESS-RESPONSE; MODEL; SYSTEM; TRANSLOCATION Multiple languages Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13301