Rive, Corvin, Reina, Giacomo ORCID: 0000-0002-8147-3162, Wagle, Prerana, Treossi, Emanuele, Palermo, Vincenzo, Bianco, Alberto, Gemma-Delogu, Lucia, Rieckher, Matthias ORCID: 0000-0002-1945-9474 and Schumacher, Bjoern (2019). Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Small, 15 (45). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1613-6829

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Abstract

Graphene oxide (GO) holds high promise for diagnostic and therapeutic applications in nanomedicine but reportedly displays immunotoxicity, underlining the need for developing functionalized GO with improved biocompatibility. This study describes adverse effects of GO and amino-functionalized GO (GONH(2)) during Caenorhabditis elegans development and ageing upon acute or chronic exposure. Chronic GO treatment throughout the C. elegans development causes decreased fecundity and a reduction of animal size, while acute treatment does not lead to any measurable physiological decline. However, RNA-Sequencing data reveal that acute GO exposure induces innate immune gene expression. The p38 MAP kinase, PMK-1, which is a well-established master regulator of innate immunity, protects C. elegans from chronic GO toxicity, as pmk-1 mutants show reduced tissue-functionality and facultative vivipary. In a direct comparison, GONH(2) exposure does not cause detrimental effects in the wild type or in pmk-1 mutants, and the innate immune response is considerably less pronounced. This work establishes enhanced biocompatibility of amino-functionalized GO in a whole-organism, emphasizing its potential as a biomedical nanomaterial.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rive, CorvinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reina, GiacomoUNSPECIFIEDorcid.org/0000-0002-8147-3162UNSPECIFIED
Wagle, PreranaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treossi, EmanueleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palermo, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bianco, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gemma-Delogu, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieckher, MatthiasUNSPECIFIEDorcid.org/0000-0002-1945-9474UNSPECIFIED
Schumacher, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-133013
DOI: 10.1002/smll.201902699
Journal or Publication Title: Small
Volume: 15
Number: 45
Date: 2019
Publisher: WILEY-V C H VERLAG GMBH
Place of Publication: WEINHEIM
ISSN: 1613-6829
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LIFE-SPAN; GERM-LINE; IN-VIVO; REPRODUCTIVE TOXICITY; INTESTINAL BARRIER; IMMUNE-RESPONSE; STRESS-RESPONSE; MODEL; SYSTEM; TRANSLOCATIONMultiple languages
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed MatterMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13301

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