Universität zu Köln

Altomare, Daniele ORCID: 0000-0003-1905-8993, Ferrari, Clarissa, Caroli, Anna ORCID: 0000-0002-4130-4663, Galluzzi, Samantha ORCID: 0000-0001-9804-5669, Prestia, Annapaola, van der Flier, Wiesje M., Ossenkoppele, Rik, Van Berckel, Bart, Barkhof, Frederik ORCID: 0000-0003-3543-3706, Teunissen, Charlotte E., Wall, Anders, Carter, Stephen F. ORCID: 0000-0002-9080-519X, Scholl, Michael ORCID: 0000-0001-7800-1781, Choo, Il Han, Grimmer, Timo, Redolfi, Alberto ORCID: 0000-0002-4145-9059, Nordberg, Agneta, Scheltens, Philip ORCID: 0000-0002-1046-6408, Drzezga, Alexander and Frisoni, Giovanni B. (2019). Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset. J. Neurol., 266 (10). S. 2535 - 2546. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

Full text not available from this repository.

Abstract

Objective The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer's biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods We measured A beta 42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose-positron emission tomography (FDG-PET) in 188 MCI patients followed for at least 1 year. We categorised patients into earlier and later onset (EO/LO). Receiver operating characteristic curves and corresponding areas under the curve (AUCs) were performed to assess and compar the biomarker prognostic performances in EO and LO groups. Linear Model was adopted for estimating the time-to-progression in relation with earlier/later onset MCI groups and biomarkers. Results In earlier onset patients, all the assessed biomarkers were able to predict cognitive decline (p < 0.05), with FDG-PET showing the best performance. In later onset patients, all biomarkers but t-tau predicted cognitive decline (p < 0.05). Moreover, FDG-PET alone in earlier onset patients showed a higher prognostic value than the one resulting from the combination of all the biomarkers in later onset patients (earlier onset AUC 0.935 vs later onset AUC 0.753, p < 0.001). Finally, FDG-PET showed a different prognostic value between earlier and later onset patients (p = 0.040) in time-to-progression allowing an estimate of the time free from disease. Discussion FDG-PET may represent the most universal tool for the establishment of a prognosis in MCI patients and may be used for obtaining an onset-related estimate of the time free from disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Ferrari, Clarissa UNSPECIFIED UNSPECIFIED UNSPECIFIED Caroli, Anna UNSPECIFIED orcid.org/0000-0002-4130-4663 UNSPECIFIED Galluzzi, Samantha UNSPECIFIED orcid.org/0000-0001-9804-5669 UNSPECIFIED Prestia, Annapaola UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Flier, Wiesje M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ossenkoppele, Rik UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Berckel, Bart UNSPECIFIED UNSPECIFIED UNSPECIFIED Barkhof, Frederik UNSPECIFIED orcid.org/0000-0003-3543-3706 UNSPECIFIED Teunissen, Charlotte E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wall, Anders UNSPECIFIED UNSPECIFIED UNSPECIFIED Carter, Stephen F. UNSPECIFIED orcid.org/0000-0002-9080-519X UNSPECIFIED Scholl, Michael UNSPECIFIED orcid.org/0000-0001-7800-1781 UNSPECIFIED Choo, Il Han UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Redolfi, Alberto UNSPECIFIED orcid.org/0000-0002-4145-9059 UNSPECIFIED Nordberg, Agneta UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheltens, Philip UNSPECIFIED orcid.org/0000-0002-1046-6408 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Frisoni, Giovanni B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133057
DOI:	10.1007/s00415-019-09441-7
Journal or Publication Title:	J. Neurol.
Volume:	266
Number:	10
Page Range:	S. 2535 - 2546
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language F-18-FDG PET; CEREBROSPINAL-FLUID; DIAGNOSTIC-CRITERIA; PREDICT CONVERSION; CSF BIOMARKERS; MCI PATIENTS; CLINICAL-USE; FOLLOW-UP; FDG-PET; DISEASE Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13305