Universität zu Köln

Hoenig, Merle C., Bischof, Gerard N., Onur, Ozgur A., Kukolja, Juraj, Jessen, Frank, Fliessbach, Klaus, Neumaier, Bernd, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Kalbe, Elke, Drzezga, Alexander and van Eimeren, Thilo (2019). Level of education mitigates the impact of tau pathology on neuronal function. Eur. J. Nucl. Med. Mol. Imaging, 46 (9). S. 1787 - 1796. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

PurposeUsing PET imaging in a group of patients with Alzheimer's disease (AD), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function.MethodsWe included 38 patients with mild-to-moderate AD (mean age 677years, mean MMSE score 244, mean years of education 14 +/- 4; 20 men, 18 women) in whom a [F-18]AV-1451 scan (a measure of tau pathology) and an [F-18]FDG scan (a measure of neuronal function) were available. The preprocessed PET scans were z-transformed using templates for [F-18]AV-1451 and [F-18]FDG from healthy controls, and subsequently thresholded at a z-score of >= 3.0, representing an one-tailed p value of 0.001. Next, three volumes were computed in each patient: the tau-specific volume (tau pathology without neuronal dysfunction), the FDG-specific volume (neuronal dysfunction without tau pathology), and the overlap volume (tau pathology and neuronal dysfunction). Mean z-scores and volumes were extracted and used as dependent variables in regression analysis with years of education as predictor, and age and MMSE score as covariates.Results Years of education were positively associated with tau-specific volume (beta=0.362, p=0.022), suggesting a lower impact of tau pathology on neuronal function in patients with higher levels of education. Concomitantly, level of education was positively related to tau burden in the overlap volume (beta=0.303, p=0.036) implying that with higher levels of education more tau pathology is necessary to induce neuronal dysfunction.Conclusion In patients with higher levels of education, tau pathology is less paralleled by regional and remote neuronal dysfunction. The data suggest that early life-time factors such as level of education support resilience mechanisms, which ameliorate AD-related effects later in life.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoenig, Merle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Ozgur A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukolja, Juraj UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-134005
DOI:	10.1007/s00259-019-04342-3
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	46
Number:	9
Page Range:	S. 1787 - 1796
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PITTSBURGH COMPOUND-B; ALZHEIMERS-DISEASE; COGNITIVE RESERVE; ENVIRONMENTAL ENRICHMENT; HYPOTHETICAL MODEL; OCCIPITAL CORTEX; TELOMERE LENGTH; GROWTH-FACTOR; BRAIN; DEMENTIA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13400