Schubert, Stephan, Opgen-Rhein, Bernd ORCID: 0000-0002-4535-4529, Boehne, Martin, Weigelt, Annika, Wagner, Robert, Mueller, Goetz, Rentzsch, Axel, zu Knyphausen, Edzard, Fischer, Marcus, Papakostas, Konstantin, Wiegand, Gesa, Ruf, Bettina, Hannes, Tobias, Reineker, Katja, Kiski, Daniela, Khalil, Markus, Steinmetz, Michael, Fischer, Gunther, Pickardt, Thomas ORCID: 0000-0003-0019-6325, Klingel, Karin, Messroghli, Daniel R., Degener, Franziska, Berger, Felix, Haverkaemper, Guido, Klaassen, Sabine, Bauer, Manuela, Racolta, Anca, Kececioglu, Deniz, Dittrich, Sven ORCID: 0000-0002-8455-3416, Halbfass, Julia, Stiller, Brigitte, Kaufmann, Janina, Bauer, Juergen, Latus, Heiner, Lux, Christian, Schranz, Dietmar, Kozlik-Feldmann, Rainer, Mir, Thomas, Schlesner, Claudia, Schmidt, Florian, Jack, Thomas, Beerbaum, Philipp, Pontius, Sandra, Abdul-Khaliq, Hashim, Brockmeier, Konrad, Daehnert, Ingo, Richter, Jacqueline, Engelhardt, Andrea, Ewert, Peter, Uebing, Anselm ORCID: 0000-0001-8504-0228, Hofbeck, Michael, Jakob, Andre, Haas, Nikolaus, Kaestner, Micheal, Apitz, Christian, Kramer, Hans-Heiner, Paul, Thomas, Freudenthal, Noa, von dem Busche, Caroline, Breuer, Johannes, Bauer, Ulrike, Dakna, Mohammed and Friede, Tim (2019). Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry MYKKE. Pediatr. Transplant., 23 (7). HOBOKEN: WILEY. ISSN 1399-3046

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Abstract

Myocarditis represents an important cause for acute heart failure. MYKKE, a prospective multicenter registry of pediatric patients with myocarditis, aims to gain knowledge on courses, diagnostics, and therapy of pediatric myocarditis. The role of mechanical circulatory support (MCS) in children with severe heart failure and myocarditis is unclear. The aim of this study was to determine characteristics and outcome of patients with severe heart failure requiring MCS and/or heart transplantation. The MYKKE cohort between September 2013 and 2016 was analyzed. A total of 195 patients were prospectively enrolled by 17 German hospitals. Twenty-eight patients (14%) received MCS (median 1.5 years), more frequently in the youngest age group (0-2 years) than in the older groups (P < 0.001; 2-12 and 13-18 years). In the MCS group, 50% received a VAD, 36% ECMO, and 14% both, with a survival rate of 79%. The weaning rate was 43% (12/28). Nine (32%) patients were transplanted, one had ongoing support, and six (21%) died. Histology was positive for myocarditis in 63% of the MCS group. Patients within the whole cohort with age <2 years and/or ejection fraction <30% had a significantly worse survival with high risk for MCS, transplantation, and death (P < 0.001). Myocarditis represents a life-threatening disease with an overall mortality of 4.6% in this cohort. The fulminant form more often affected the youngest, leading to significantly higher rate of MCS, transplantation, and mortality. MCS represents an important and life-saving therapeutic option in children with myocarditis with a weaning rate of 43%.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schubert, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opgen-Rhein, BerndUNSPECIFIEDorcid.org/0000-0002-4535-4529UNSPECIFIED
Boehne, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigelt, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, GoetzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rentzsch, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
zu Knyphausen, EdzardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papakostas, KonstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiegand, GesaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hannes, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reineker, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiski, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khalil, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinmetz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, GuntherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pickardt, ThomasUNSPECIFIEDorcid.org/0000-0003-0019-6325UNSPECIFIED
Klingel, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Messroghli, Daniel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degener, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haverkaemper, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaassen, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racolta, AncaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kececioglu, DenizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dittrich, SvenUNSPECIFIEDorcid.org/0000-0002-8455-3416UNSPECIFIED
Halbfass, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stiller, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufmann, JaninaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Latus, HeinerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lux, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schranz, DietmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozlik-Feldmann, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mir, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlesner, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jack, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beerbaum, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pontius, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abdul-Khaliq, HashimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockmeier, KonradUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daehnert, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, JacquelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelhardt, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewert, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uebing, AnselmUNSPECIFIEDorcid.org/0000-0001-8504-0228UNSPECIFIED
Hofbeck, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakob, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, NikolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaestner, MichealUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apitz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kramer, Hans-HeinerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freudenthal, NoaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von dem Busche, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breuer, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dakna, MohammedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friede, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-135238
DOI: 10.1111/petr.13548
Journal or Publication Title: Pediatr. Transplant.
Volume: 23
Number: 7
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1399-3046
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUDDEN CARDIAC DEATH; ACUTE-FULMINANT; DIAGNOSIS; CHILDREN; CARDIOMYOPATHY; CARDIOLOGY; OUTCOMES; SOCIETY; DEFINITIONMultiple languages
Pediatrics; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13523

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