Hagens, Eliza R. C., Henegouwen, Mark I. van Berge, van Sandick, Johanna W., Cuesta, Miguel A., van der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A. P., Rosman, Camiel ORCID: 0000-0002-9152-3987, Scheepers, Joris J. G., Sosef, Meindert N., van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Rasanen, Jari, Nafteux, Philippe, Pattyn, Piet, Hoelscher, Arnulf H., Schroeder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, de Manzoni, Giovanni, Mattioli, Sandro, Roig Garcia, Josep, Pera, Manuel ORCID: 0000-0002-9449-1810, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin-ichi, Chen, Haiquan, Law, Simon Y. K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flavio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J. G. H. M., Hulshof, Maarten C. C. M., van Laarhoven, Hanneke W. M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G. W. and Gisbertz, Suzanne S. (2019). Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study. BMC Cancer, 19. LONDON: BMC. ISSN 1471-2407

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Abstract

BackgroundAn important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients.MethodsThe TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival.DiscussionThe TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics.Trial registrationNCT03222895, date of registration: July 19th, 2017.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hagens, Eliza R. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henegouwen, Mark I. van BergeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Sandick, Johanna W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuesta, Miguel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Peet, Donald L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heisterkamp, JoosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nieuwenhuijzen, Grard A. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosman, CamielUNSPECIFIEDorcid.org/0000-0002-9152-3987UNSPECIFIED
Scheepers, Joris J. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sosef, Meindert N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Hillegersberg, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagarde, Sjoerd M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilsson, MagnusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rasanen, JariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nafteux, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pattyn, PietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, Arnulf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, Paul M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mariette, ChristopheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castoro, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonavina, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosati, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Manzoni, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mattioli, SandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roig Garcia, JosepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pera, ManuelUNSPECIFIEDorcid.org/0000-0002-9449-1810UNSPECIFIED
Griffin, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilkerson, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaudry, M. AsifUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sgromo, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tucker, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheong, EdwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moorthy, KrishnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, Thomas N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reynolds, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tachimori, YujiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Inoue, HaruhiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matsubara, HisahiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosugi, Shin-ichiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, HaiquanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Law, Simon Y. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pramesh, C. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puntambekar, Shailesh P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murthy, SudishUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linden, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofstetter, Wayne L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuppusamy, Madhan K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shen, K. RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Darling, Gail E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabino, Flavio D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimminger, Peter P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meijer, Sybren L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergman, Jacques J. G. H. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hulshof, Maarten C. C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Laarhoven, Hanneke W. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mearadji, BanafscheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bennink, Roel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Annema, Jouke T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dijkgraaf, Marcel G. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gisbertz, Suzanne S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-135478
DOI: 10.1186/s12885-019-5761-7
Journal or Publication Title: BMC Cancer
Volume: 19
Date: 2019
Publisher: BMC
Place of Publication: LONDON
ISSN: 1471-2407
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SQUAMOUS-CELL; CANCER; ADENOCARCINOMA; PATTERN; SPREAD; LYMPHADENECTOMY; DISSECTION; IMPACTMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13547

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