Shih, Andrew W., Cohn, Claudia S., Delaney, Meghan, Fontaine, Magali J., Martin, Isabella, Dunbar, Nancy M. ORCID: 0000-0001-8601-5438, Dagger, John, Fadeyi, Emmanuel A., Flanagan, Peter, Gathof, Birgit, Godbey, Elizabeth A., Harach, Mary, Huggins, Y. Monique, Ipe, Tina S., Jackson, Bryon, Jacquot, Cyril, Jin, Zhongbo, Jones, Mary Rose, Kamel, Hany, Karp, Julie K., Lewin, Antoine, Mo, Yunchuan, Murphy, Mike, O'Brien, Jennifer, Ommer, Katharina, Pagano, Monica B., Passwater, Michael, Pelletier, J. Peter R., Robillard, Pierre, Schwartz, Joseph, Sham, Lawrence, Shunkwiler, Sara M., Simmons, Julie S., Staves, Julie, Takanaski, Minoko, Vasallo, Ralph, Weiss, Susan, Williams, Shelly M., Yamada, Chisa, Young, Pampee P. and Ziman, Alyssa (2019). The BEST criteria improve sensitivity for detecting positive cultures in residual blood components cultured in suspected septic transfusion reactions. Transfusion, 59 (7). S. 2292 - 2301. HOBOKEN: WILEY. ISSN 1537-2995

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Abstract

BACKGROUND: Culturing residual blood components after suspected septic transfusion reactions guides management of patients and cocomponents. Current practice, accuracy of provider vital sign assessment, and performance of the AABB culture criteria are unknown. A multicenter international study was undertaken to investigate these issues and develop improved culture criteria. STUDY DESIGN AND METHODS: Retrospective data for all transfusion reactions resulting in residual blood component culture in 2016 were collected from participating hospitals. The performance of the AABB culture criteria were assessed for detection of positive culture results. Modifications to the AABB criteria including 1) recommending culturing in the setting of isolated high fevers, 2) defining hypotension and tachycardia using objective parameters, and 3) incorporating antipyretic use were tested to determine if modifications improved performance. Modifications associated with improvement were incorporate into the BEST criteria. The AABB and the BEST criteria were then tested against a data set enriched for positive culture results to determine which criteria were superior. RESULTS: Data were collected from 20 centers encompassing 779,143 transfusions, 3,187 reported transfusion reactions, and 1,104 cultured components. There was marked variation in reaction reporting and culturing rates (0.0%-100.0%). Of 35 total positive component cultures, only one of 35 (2.9%) had concordant patient cultures; 12 of 34 (35.3%) did not have patient cultures performed. The BEST criteria had better sensitivity for detection of a positive culture result compared to the AABB criteria (74% vs. 41%), although specificity decreased (45% vs. 65%). CONCLUSION: Compared to the AABB criteria, the BEST criteria have improved sensitivity for positive culture detection.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Shih, Andrew W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohn, Claudia S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delaney, MeghanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fontaine, Magali J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunbar, Nancy M.UNSPECIFIEDorcid.org/0000-0001-8601-5438UNSPECIFIED
Dagger, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fadeyi, Emmanuel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flanagan, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gathof, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Godbey, Elizabeth A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harach, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huggins, Y. MoniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ipe, Tina S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jackson, BryonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacquot, CyrilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jin, ZhongboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, Mary RoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamel, HanyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karp, Julie K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewin, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mo, YunchuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murphy, MikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Brien, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ommer, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pagano, Monica B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Passwater, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelletier, J. Peter R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robillard, PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwartz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sham, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shunkwiler, Sara M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simmons, Julie S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staves, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takanaski, MinokoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasallo, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, Shelly M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yamada, ChisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Young, Pampee P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziman, AlyssaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-135753
DOI: 10.1111/trf.15317
Journal or Publication Title: Transfusion
Volume: 59
Number: 7
Page Range: S. 2292 - 2301
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1537-2995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSMITTED BACTERIAL-INFECTION; PLATELETS; RISKMultiple languages
HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13575

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