Universität zu Köln

Jordan, Jens, Hildebrand, Staffan ORCID: 0000-0003-1889-907X and Pfeifer, Alexander (2019). cGMP manipulation in cardiometabolic disease: chances and challenges. Curr. Opin. Cardiol., 34 (4). S. 376 - 384. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1531-7080

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Abstract

Purpose of review Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate ( cGMP) system and its crosstalk between metabolism and the cardiovascular system. Recent findings Recent studies suggest that cGMP, which serves as second messenger for nitric oxide and for natriuretic peptides, improves oxidative metabolism and insulin signaling. The clinical evidence is particularly strong for the natriuretic peptide branch of the cGMP system. Clinical trials suggested improvements in insulin sensitivity and reductions in the risk of progressing to type 2 diabetes mellitus. However, further studies are needed. Summary Enhancing cGMP signaling through nonpharmacological or pharmacological means may improve glucose metabolism in addition to affecting the cardiovascular system. However, excessive cGMP production could have significant unwanted cardiovascular and metabolic effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Hildebrand, Staffan UNSPECIFIED orcid.org/0000-0003-1889-907X UNSPECIFIED Pfeifer, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-135922
DOI:	10.1097/HCO.0000000000000630
Journal or Publication Title:	Curr. Opin. Cardiol.
Volume:	34
Number:	4
Page Range:	S. 376 - 384
Date:	2019
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1531-7080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATRIAL-NATRIURETIC-PEPTIDE; INSULIN SENSITIVITY; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MITOCHONDRIAL BIOGENESIS; WEIGHT-LOSS; NEPRILYSIN INHIBITION; BLOOD-PRESSURE; HEART-FAILURE; EXERCISE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13592