Werner, Jan-Michael, Brunn, Anna, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Galldiks, Norbert
ORCID: 0000-0002-2485-1796
(2019).
Magnetic Resonance Imaging Reveals a Pronounced Treatment Response of a Isocitrate Dehydrogenase- and B-Raf Proto-Oncogene-Wildtype Epithelioid Glioblastoma.
World Neurosurg., 127.
S. 213 - 216.
NEW YORK:
ELSEVIER SCIENCE INC.
ISSN 1878-8769
Abstract
We here report findings on magnetic resonance imaging from a 60-year-old patient with an epithelioid glioblastoma of the corpus callosum treated with radiotherapy in combination with concomitant and adjuvant temozolomide. Neuropathology revealed a highly aggressive molecular subtype of the epithelioid glioblastoma without an isocitrate dehydrogenase and B-Raf proto-oncogene mutation or a 06-methylguanine-DNA-methyltransferase promoter hypermethylation. This subtype is typically associated with an unfavorable clinical course and poor overall survival. Unexpectedly, the first follow-up magnetic resonance imaging 10 weeks after chemoradiation completion revealed an early and almost complete treatment response.
Item Type: | Journal Article | ||||||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-136668 | ||||||||||||||||||||
DOI: | 10.1016/j.wneu.2019.04.025 | ||||||||||||||||||||
Journal or Publication Title: | World Neurosurg. | ||||||||||||||||||||
Volume: | 127 | ||||||||||||||||||||
Page Range: | S. 213 - 216 | ||||||||||||||||||||
Date: | 2019 | ||||||||||||||||||||
Publisher: | ELSEVIER SCIENCE INC | ||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||
ISSN: | 1878-8769 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/13666 |
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