Universität zu Köln

Zlatopolskiy, Boris D., Zischler, Johannes ORCID: 0000-0003-3996-7473, Krapf, Philipp ORCID: 0000-0003-1671-2443, Richarz, Raphael, Lauchner, Katharina and Neumaier, Bernd ORCID: 0000-0001-5425-3116 (2019). Minimalist approach meets green chemistry: Synthesis of F-18- labeled (hetero)aromatics in pure ethanol. J. Label. Compd. Radiopharm., 62 (8). S. 404 - 411. HOBOKEN: WILEY. ISSN 1099-1344

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Abstract

The application of toxic solvents and additives is inevitable for most of the described protocols for F-18-labeling. Herein, a novel green procedure for nucleophilic aromatic radiofluorination of highly activated (hetero)aromatic substrates in pure EtOH is described. Using this method a series of F-18-labeled (hetero)arenes have been synthesized in radiochemical yields (RCYs) of up to 97%.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zlatopolskiy, Boris D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zischler, Johannes UNSPECIFIED orcid.org/0000-0003-3996-7473 UNSPECIFIED Krapf, Philipp UNSPECIFIED orcid.org/0000-0003-1671-2443 UNSPECIFIED Richarz, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lauchner, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137336
DOI:	10.1002/jlcr.3776
Journal or Publication Title:	J. Label. Compd. Radiopharm.
Volume:	62
Number:	8
Page Range:	S. 404 - 411
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1099-1344
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PET; RADIOFLUORINATION; FLUORINATION Multiple languages Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13733