Kersten, Eveline, Dammeier, Sascha, Ajana, Soufiane, Groenewoud, Joannes M. M., Codrea, Marius, Klose, Franziska, Lechanteur, Yara T., Fauser, Sascha, Ueffing, Marius, Delcourt, Cecile ORCID: 0000-0002-2099-0481, Hoyng, Carel B., de Jong, Eiko K., den Hollander, Anneke I., Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnes, Marc, Borrell, Anna, Buhren, Sebastian, Calado, Sofia M. ORCID: 0000-0001-5509-4145, Colijn, Johanna M., Cougnard-Gregoire, Audrey, de Jong, Eiko, De la Cerda, Berta, Diaz-Corrales, F. J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia, Garcia, Miriam, Heesterbeek, Thomas J., Honisch, Sabina, Iacone, Roberto, Kilger, Ellen, Klaver, Caroline C. W., Langen, Hanno, Lengyel, Imre ORCID: 0000-0001-7467-2174, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Benedicte, Mones, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Fran, Rodriguez, Eduardo, Bartz-Schmidt, Karl Ulrich, van Leeuwen, Elisabeth M., Verzijden, Timo and Zumbansen, Markus (2019). Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway. PLoS One, 14 (6). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Age-related macular degeneration (AMD) is a common, progressive multifactorial vision-threatening disease and many genetic and environmental risk factors have been identified. The risk of AMD is influenced by lifestyle and diet, which may be reflected by an altered metabolic profile. Therefore, measurements of metabolites could identify biomarkers for AMD, and could aid in identifying high-risk individuals. Hypothesis-free technologies such as metabolomics have a great potential to uncover biomarkers or pathways that contribute to disease pathophysiology. To date, only a limited number of metabolomic studies have been performed in AMD. Here, we aim to contribute to the discovery of novel biomarkers and metabolic pathways for AMD using a targeted metabolomics approach of 188 metabolites. This study focuses on non-advanced AMD, since there is a need for biomarkers for the early stages of disease before severe visual loss has occurred. Targeted metabolomics was performed in 72 patients with early or intermediate AMD and 72 control individuals, and metabolites predictive for AMD were identified by a sparse partial least squares discriminant analysis. In our cohort, we identified four metabolite variables that were most predictive for early and intermediate stages of AMD. Increased glutamine and phosphatidylcholine diacyl C28:1 levels were detected in non-advanced AMD cases compared to controls, while the rate of glutaminolysis and the glutamine to glutamate ratio were reduced in non-advanced AMD. The association of glutamine with non-advanced AMD corroborates a recent report demonstrating an elevated glutamine level in early AMD using a different metabolomics technique. In conclusion, this study indicates that metabolomics is a suitable method for the discovery of biomarker candidates for AMD. In the future, larger metabolomics studies could add to the discovery of novel biomarkers in yet unknown AMD pathways and expand our insights in AMD pathophysiology.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kersten, EvelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dammeier, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ajana, SoufianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groenewoud, Joannes M. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Codrea, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klose, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lechanteur, Yara T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fauser, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ueffing, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delcourt, CecileUNSPECIFIEDorcid.org/0000-0002-2099-0481UNSPECIFIED
Hoyng, Carel B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jong, Eiko K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
den Hollander, Anneke I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arango-Gonzalez, BlancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arndt, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhatia, VaibhavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhattacharya, Shomi S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biarnes, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borrell, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buhren, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calado, Sofia M.UNSPECIFIEDorcid.org/0000-0001-5509-4145UNSPECIFIED
Colijn, Johanna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cougnard-Gregoire, AudreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jong, EikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De la Cerda, BertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diaz-Corrales, F. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diether, SigridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emri, EszterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Endermann, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferraro, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesterbeek, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Honisch, SabinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacone, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilger, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaver, Caroline C. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langen, HannoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lengyel, ImreUNSPECIFIEDorcid.org/0000-0001-7467-2174UNSPECIFIED
Luthert, PhilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maugeais, CyrilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meester-Smoor, MagdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merle, BenedicteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mones, JordiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogoceke, EversonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, TundeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pool, FranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartz-Schmidt, Karl UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, Elisabeth M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verzijden, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zumbansen, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-137568
DOI: 10.1371/journal.pone.0218457
Journal or Publication Title: PLoS One
Volume: 14
Number: 6
Date: 2019
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYSTEMIC COMPLEMENT ACTIVATION; PREVALENCEMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13756

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