Universität zu Köln

Ho, Bryan Siu-Yin, Vaz, Candida ORCID: 0000-0002-6650-7889, Ramasamy, Srinivas, Chew, Elaine Guo Yan, Mohamed, Jameelah Sheik, Jaffar, Huma, Hillmer, Axel, Tanavde, Vivek ORCID: 0000-0001-7404-5568, Bigliardi-Qi, Mei and Bigliardi, Paul Lorenz ORCID: 0000-0003-4567-9080 (2019). Progressive expression of PPARGC1 alpha is associated with hair miniaturization in androgenetic alopecia. Sci Rep, 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Current opinion views androgens as the pathogenic driver in the miniaturization of hair follicles of androgenetic alopecia by interfering with the dermal papilla. This cannot be the sole cause and therefore it is important for therapeutic and diagnostic purposes to identify additional pathways. Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization. We demonstrate the concurrent up-regulation of PPARGC1 alpha in the epithelial compartment and androgen receptor in the dermal papilla of miniaturized hair. Dynamic Ppargc1 alpha expression in the mouse hair cycle suggests a possible role in regulating hair growth and differentiation. This is supported by reduced proliferation of human dermal papilla and predominantly epithelial keratinocytes after incubation with AICAR, the agonist for AMPK signaling which activates PPARGC1 alpha and serves as co-activator of PPAR gamma. In addition, miRNA profiling shows enrichment of miRNA-targeted genes in retinoid receptors and PPARGC1 alpha/PPAR gamma signaling, and antigen presentation pathways.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ho, Bryan Siu-Yin UNSPECIFIED UNSPECIFIED UNSPECIFIED Vaz, Candida UNSPECIFIED orcid.org/0000-0002-6650-7889 UNSPECIFIED Ramasamy, Srinivas UNSPECIFIED UNSPECIFIED UNSPECIFIED Chew, Elaine Guo Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohamed, Jameelah Sheik UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaffar, Huma UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillmer, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Tanavde, Vivek UNSPECIFIED orcid.org/0000-0001-7404-5568 UNSPECIFIED Bigliardi-Qi, Mei UNSPECIFIED UNSPECIFIED UNSPECIFIED Bigliardi, Paul Lorenz UNSPECIFIED orcid.org/0000-0003-4567-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137635
DOI:	10.1038/s41598-019-43998-7
Journal or Publication Title:	Sci Rep
Volume:	9
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DERMAL PAPILLA CELLS; PROLIFERATOR-ACTIVATED RECEPTORS; MALE PATTERN BALDNESS; DIFFERENTIAL EXPRESSION; ENERGY-METABOLISM; ADIPOSE-TISSUE; GROWTH; PGC-1-ALPHA; FOLLICLES; COACTIVATOR Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13763