Bassetti, Matteo ORCID: 0000-0002-0145-9740, Giacobbe, Daniele R., Vena, Antonio ORCID: 0000-0002-0697-3992, Trucchi, Cecilia, Ansaldi, Filippo, Antonelli, Massimo, Adamkova, Vaclava, Alicino, Cristiano, Almyroudi, Maria-Panagiota, Atchade, Enora, Azzini, Anna M., Carannante, Novella, Carnelutti, Alessia, Corcione, Silvia, Cortegiani, Andrea ORCID: 0000-0003-1416-9993, Dimopoulos, George ORCID: 0000-0002-3784-3103, Dubler, Simon, Garcia-Garmendia, Jose L., Girardis, Massimo ORCID: 0000-0002-2453-0829, Cornely, Oliver A., Ianniruberto, Stefano, Kullberg, Bart Jan, Lagrou, Katrien, Le Bihan, Clement, Luzzati, Roberto ORCID: 0000-0001-5546-0715, Malbrain, Manu L. N. G., Merelli, Maria, Marques, Ana J., Martin-Loeches, Ignacio, Mesini, Alessio ORCID: 0000-0003-0593-4112, Paiva, Jose-Artur ORCID: 0000-0003-4323-0220, Peghin, Maddalena, Raineri, Santi Maurizio, Rautemaa-Richardson, Riina, Schouten, Jeroen, Brugnaro, Pierluigi, Spapen, Herbert ORCID: 0000-0002-7724-886X, Tasioudis, Polychronis, Timsit, Jean-Francois, Tisa, Valentino, Tumbarello, Mario, van den Berg, Charlotte H. S. B., Veber, Benoit, Venditti, Mario, Voiriot, Guillaume, Wauters, Joost and Montravers, Philippe (2019). Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project. Crit. Care, 23. LONDON: BMC. ISSN 1364-8535

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Abstract

BackgroundThe objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe.MethodsA multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU).ResultsDuring the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p<0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis.ConclusionsThe cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bassetti, MatteoUNSPECIFIEDorcid.org/0000-0002-0145-9740UNSPECIFIED
Giacobbe, Daniele R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vena, AntonioUNSPECIFIEDorcid.org/0000-0002-0697-3992UNSPECIFIED
Trucchi, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansaldi, FilippoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonelli, MassimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adamkova, VaclavaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alicino, CristianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Almyroudi, Maria-PanagiotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atchade, EnoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azzini, Anna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carannante, NovellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carnelutti, AlessiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corcione, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cortegiani, AndreaUNSPECIFIEDorcid.org/0000-0003-1416-9993UNSPECIFIED
Dimopoulos, GeorgeUNSPECIFIEDorcid.org/0000-0002-3784-3103UNSPECIFIED
Dubler, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Garmendia, Jose L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Girardis, MassimoUNSPECIFIEDorcid.org/0000-0002-2453-0829UNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ianniruberto, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kullberg, Bart JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagrou, KatrienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Bihan, ClementUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luzzati, RobertoUNSPECIFIEDorcid.org/0000-0001-5546-0715UNSPECIFIED
Malbrain, Manu L. N. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merelli, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marques, Ana J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin-Loeches, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mesini, AlessioUNSPECIFIEDorcid.org/0000-0003-0593-4112UNSPECIFIED
Paiva, Jose-ArturUNSPECIFIEDorcid.org/0000-0003-4323-0220UNSPECIFIED
Peghin, MaddalenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raineri, Santi MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rautemaa-Richardson, RiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schouten, JeroenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brugnaro, PierluigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spapen, HerbertUNSPECIFIEDorcid.org/0000-0002-7724-886XUNSPECIFIED
Tasioudis, PolychronisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timsit, Jean-FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tisa, ValentinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tumbarello, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Berg, Charlotte H. S. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veber, BenoitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venditti, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voiriot, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wauters, JoostUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montravers, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-137819
DOI: 10.1186/s13054-019-2497-3
Journal or Publication Title: Crit. Care
Volume: 23
Date: 2019
Publisher: BMC
Place of Publication: LONDON
ISSN: 1364-8535
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTRAABDOMINAL CANDIDIASIS; EPIDEMIOLOGY; CANDIDEMIA; MULTICENTER; PREDICTORS; MANAGEMENTMultiple languages
Critical Care MedicineMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13781

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