Universität zu Köln

Ruud, Johan, Alber, Jens, Tokarska, Anna ORCID: 0000-0001-9734-2354, Ruud, Linda Engstroem, Nolte, Hendrik, Biglari, Nasim, Lippert, Rachel ORCID: 0000-0002-6905-2234, Lautenschlager, Anne, Ciealak, Przemyslaw E., Szumiec, Lukasz, Hess, Martin E., Broenneke, Hella S., Krueger, Marcus ORCID: 0000-0003-2008-4582, Nissbrandt, Hans, Korotkova, Tatiana, Silberberg, Gilad ORCID: 0000-0001-9964-505X, Parkitna, Jan Rodriguez and Bruening, Jens C. (2019). The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell Reports, 27 (11). S. 3182 - 3208. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Full text not available from this repository.

Abstract

Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neurons (D2 MSNs) of mice regulate the excitability of these cells and control their striatopallidal globus pallidus external (GPe) projections. Lack of FTO in D2 MSNs translates into increased locomotor activity to novelty, associated with altered timing behavior, without impairing the ability to control actions or affecting reward-driven and conditioned behavior. Pharmacological manipulations of dopamine D1 receptor (D1R)- or D2R-dependent pathways in these animals reveal altered responses to D1- and D2-MSN-mediated control of motor output. These findings reveal a critical role for FTO to control D2 MSN excitability, their projections to the GPe, and behavioral responses to novelty.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ruud, Johan UNSPECIFIED UNSPECIFIED UNSPECIFIED Alber, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tokarska, Anna UNSPECIFIED orcid.org/0000-0001-9734-2354 UNSPECIFIED Ruud, Linda Engstroem UNSPECIFIED UNSPECIFIED UNSPECIFIED Nolte, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Biglari, Nasim UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippert, Rachel UNSPECIFIED orcid.org/0000-0002-6905-2234 UNSPECIFIED Lautenschlager, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciealak, Przemyslaw E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Szumiec, Lukasz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hess, Martin E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broenneke, Hella S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger, Marcus UNSPECIFIED orcid.org/0000-0003-2008-4582 UNSPECIFIED Nissbrandt, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Korotkova, Tatiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Silberberg, Gilad UNSPECIFIED orcid.org/0000-0001-9964-505X UNSPECIFIED Parkitna, Jan Rodriguez UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137915
DOI:	10.1016/j.celrep.2019.05.037
Journal or Publication Title:	Cell Reports
Volume:	27
Number:	11
Page Range:	S. 3182 - 3208
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENE-EXPRESSION; NEURAL MECHANISMS; MICE; RNA; VARIANT; INTERNEURONS; METHYLATION; IMPULSIVITY; IDENTIFICATION; ENRICHMENT Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13791