Universität zu Köln

Mundorf, Juliane, Donohoe, Colin D., McClure, Colin D., Southall, Tony D. and Uhlirova, Mirka ORCID: 0000-0002-5735-8287 (2019). Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine. Cell Reports, 27 (10). S. 3019 - 3039. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

Homeostatic renewal and stress-related tissue regeneration rely on stem cell activity, which drives the replacement of damaged cells to maintain tissue integrity and function. The Jun N-terminal kinase (JNK) signaling pathway has been established as a critical regulator of tissue homeostasis both in intestinal stem cells (ISCs) and mature enterocytes (ECs), while its chronic activation has been linked to tissue degeneration and aging. Here, we show that JNK signaling requires the stress-inducible transcription factor Ets21c to promote tissue renewal in Drosophila. We demonstrate that Ets21c controls ISC proliferation as well as EC apoptosis through distinct sets of target genes that orchestrate cellular behaviors via intrinsic and non-autonomous signaling mechanisms. While its loss appears dispensable for development and prevents epithelial aging, ISCs and ECs demand Ets21c function to mount cellular responses to oxidative stress. Ets21c thus emerges as a vital regulator of proliferative homeostasis in the midgut and a determinant of the adult healthspan.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mundorf, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Donohoe, Colin D. UNSPECIFIED UNSPECIFIED UNSPECIFIED McClure, Colin D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Southall, Tony D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhlirova, Mirka UNSPECIFIED orcid.org/0000-0002-5735-8287 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138178
DOI:	10.1016/j.celrep.2019.05.025
Journal or Publication Title:	Cell Reports
Volume:	27
Number:	10
Page Range:	S. 3019 - 3039
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN-DNA INTERACTIONS; STEM-CELL PROLIFERATION; GENE-EXPRESSION; OXIDATIVE STRESS; HOMEOSTASIS; ACTIVATION; GUT; AUTOCRINE; AUTOPHAGY; INSIGHTS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13817