Universität zu Köln

Collmann, Franziska M., Pijnenburg, Rory, Hamzei-Taj, Somayyeh, Minassian, Anuka, Folz-Donahue, Kat, Kukat, Christian ORCID: 0000-0003-1508-0229, Aswendt, Markus ORCID: 0000-0003-1423-0934 and Hoehn, Mathias (2019). Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1. Front. Immunol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

Microglia are the brain-innate immune cells which actively surveil their environment and mediate multiple aspects of neuroinflammation, due to their ability to acquire diverse activation states and phenotypes. Simplified, M1-like microglia are defined as pro-inflammatory cells, while the alternative M2-like cells promote neuroprotection. The modulation of microglia polarization is an appealing neurotherapeutic strategy for stroke and other brain lesions, as well as neurodegenerative diseases. However, the activation profile and change of phenotype during experimental stroke is not well understood. With a combined magnetic resonance imaging (MRI) and optical imaging approach and genetic targeting of two key genes of the M1- and M2-like phenotypes, iNOS and Ym1, we were able to monitor in vivo the dynamic adaption of the microglia phenotype in response to experimental stroke.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Collmann, Franziska M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pijnenburg, Rory UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamzei-Taj, Somayyeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Minassian, Anuka UNSPECIFIED UNSPECIFIED UNSPECIFIED Folz-Donahue, Kat UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukat, Christian UNSPECIFIED orcid.org/0000-0003-1508-0229 UNSPECIFIED Aswendt, Markus UNSPECIFIED orcid.org/0000-0003-1423-0934 UNSPECIFIED Hoehn, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138185
DOI:	10.3389/fimmu.2019.01236
Journal or Publication Title:	Front. Immunol.
Volume:	10
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-3224
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NITRIC-OXIDE SYNTHASE; ISCHEMIC BRAIN-INJURY; MICROGLIA/MACROPHAGE POLARIZATION; CEREBRAL-ISCHEMIA; GLOBAL-ISCHEMIA; RAT-BRAIN; ACTIVATION; EXPRESSION; CELLS; MODULATION Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13818