Universität zu Köln

Sun, Yu, Wang, Xiaoni, Wang, Yinshan, Dong, Haoming, Lu, Jie, Scheininger, Tohar, Ewers, Michael, Jessen, Frank, Zuo, Xi-Nian ORCID: 0000-0001-9110-585X and Han, Ying ORCID: 0000-0003-0377-7424 (2019). Anxiety correlates with cortical surface area in subjective cognitive decline: APOE epsilon 4 carriers versus APOE epsilon 4 non-carriers. Alzheimers Res. Ther., 11. LONDON: BMC. ISSN 1758-9193

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Abstract

BackgroundSubjective cognitive decline (SCD) is characterized by self-reported cognitive deficits without measurable cognitive impairment. It has been suggested that individuals with SCD exhibited brain structural alterations in widespread cortical thinning or gray matter loss in the medial temporal and frontotemporal regions. Apolipoprotein E (APOE) epsilon 4 allele is thought to be a genetic marker associated with risk of SCD. Neuropsychiatric symptoms may provide insight in detecting higher-risk elders for early Alzheimer's disease as well. Therefore, we aim to explore the characteristics of brain morphology in SCD and to determine whether it is influenced by APOE epsilon 4 as well as neuropsychiatric symptoms in SCD.MethodsA total of 138 cognitively normal older individuals from the SILCODE cohort underwent a clinical interview, neuropsychological assessments, a blood test, and MRI. A two-sample t-test was used to examine the cortex volume and bilateral cortical surface area alterations between SCD (n = 65) and controls (n = 73). A general linear model analysis was used to test for both main and interaction effects of clinical phenotype (SCD vs. controls) and APOE on global and regional cortex volume and bilateral cortical surface area and thickness. A multiple linear regression analysis was conducted to determine the effects of the APOE genotype on the relationships between morphometric features and neuropsychiatric symptoms in SCD.ResultsCompared with controls, individuals with SCD showed decreased total cortical volumes and cortical surface area. SCD APOE epsilon 4 carriers showed additive reduction in the right cortical surface area. The evaluation scores of anxiety symptoms were negatively associated with the right cortical surface area in SCD APOE 4 non-carriers.ConclusionsIndividuals with SCD had an altered cortical surface area, and APOE genotype and anxiety symptoms are modified factors on the cortical surface area decrease in SCD.Trial registrationClinicalTrials.gov (Identifier: NCT03370744). Registered 15 March 2017.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sun, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Yinshan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Haoming UNSPECIFIED UNSPECIFIED UNSPECIFIED Lu, Jie UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheininger, Tohar UNSPECIFIED UNSPECIFIED UNSPECIFIED Ewers, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Zuo, Xi-Nian UNSPECIFIED orcid.org/0000-0001-9110-585X UNSPECIFIED Han, Ying UNSPECIFIED orcid.org/0000-0003-0377-7424 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138236
DOI:	10.1186/s13195-019-0505-0
Journal or Publication Title:	Alzheimers Res. Ther.
Volume:	11
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1758-9193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN CEREBRAL-CORTEX; AMYLOID-BETA; OLDER-ADULTS; RECOGNITION MEMORY; THICKNESS; VOLUME; INDIVIDUALS; ASSOCIATION; IMPAIRMENT; SYMPTOMS Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13823