Universität zu Köln

Yu, Haidong ORCID: 0000-0001-6039-6076, Dilbaz, Sedat, Cossmann, Jonas, Hoang, Anh Cuong, Diedrich, Victoria, Herwig, Annika, Harauma, Akiko, Hoshi, Yukino, Moriguchi, Toru, Landgraf, Kathrin, Koerner, Antje, Lucas, Christina, Brodesser, Susanne, Balogh, Lajos, Thuroczy, Julianna, Karemore, Gopal ORCID: 0000-0002-7285-0624, Kuefner, Michael Scott, Park, Edwards A., Rapp, Christine, Travers, Jeffrey Bryant and Roeszer, Tames (2019). Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. J. Clin. Invest., 129 (6). S. 2485 - 2500. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

Full text not available from this repository.

Abstract

Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yu, Haidong UNSPECIFIED orcid.org/0000-0001-6039-6076 UNSPECIFIED Dilbaz, Sedat UNSPECIFIED UNSPECIFIED UNSPECIFIED Cossmann, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoang, Anh Cuong UNSPECIFIED UNSPECIFIED UNSPECIFIED Diedrich, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Herwig, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Harauma, Akiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoshi, Yukino UNSPECIFIED UNSPECIFIED UNSPECIFIED Moriguchi, Toru UNSPECIFIED UNSPECIFIED UNSPECIFIED Landgraf, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerner, Antje UNSPECIFIED UNSPECIFIED UNSPECIFIED Lucas, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Brodesser, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Balogh, Lajos UNSPECIFIED UNSPECIFIED UNSPECIFIED Thuroczy, Julianna UNSPECIFIED UNSPECIFIED UNSPECIFIED Karemore, Gopal UNSPECIFIED orcid.org/0000-0002-7285-0624 UNSPECIFIED Kuefner, Michael Scott UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, Edwards A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rapp, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Travers, Jeffrey Bryant UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeszer, Tames UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138243
DOI:	10.1172/JCI125646
Journal or Publication Title:	J. Clin. Invest.
Volume:	129
Number:	6
Page Range:	S. 2485 - 2500
Date:	2019
Publisher:	AMER SOC CLINICAL INVESTIGATION INC
Place of Publication:	ANN ARBOR
ISSN:	1558-8238
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED RECEPTOR-GAMMA; FACTOR ACETYLHYDROLASE; INSULIN-RESISTANCE; BOVINE COLOSTRUM; EARLY-CHILDHOOD; PROTEIN-KINASE; DEFICIENT MICE; FATTY-ACIDS; DIET; OBESITY Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13824