Universität zu Köln

Wennhold, Kerstin, Shimabukuro-Vornhagen, Alexander and von Bergwelt-Baildon, Michael (2019). B Cell-Based Cancer Immunotherapy. Transfus. Med. Hemother., 46 (1). S. 36 - 47. BASEL: KARGER. ISSN 1660-3818

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Abstract

B cells are not only producers of antibodies, but also contribute to immune regulation or act as potent antigen-presenting cells. The potential of B cells for cellular therapy is still largely underestimated, despite their multiple diverse effector functions. The CD40L/CD40 signaling pathway is the most potent activator of antigen presentation capacity in B lymphocytes. CD40-activated B cells are potent antigen-presenting cells that induce specific T-cell responses in vitro and in vivo. In preclinical cancer models in mice and dogs, CD40-activated B cell-based cancer immunotherapy was able to induce effective antitumor immunity. So far, there have been only few early-stage clinical studies involving B cell-based cancer vaccines. These trials indicate that B cell-based immunotherapy is generally safe and associated with little toxicity. Furthermore, these studies suggest that B-cell immunotherapy can elicit antitumor T-cell responses. Alongside the recent advances in cellular therapies in general, major obstacles for generation of good manufacturing practice-manufactured B-cell immunotherapies have been overcome. Thus, a first clinical trial involving CD40-activated B cells might be in reach. (C) 2019 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wennhold, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139370
DOI:	10.1159/000496166
Journal or Publication Title:	Transfus. Med. Hemother.
Volume:	46
Number:	1
Page Range:	S. 36 - 47
Date:	2019
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1660-3818
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIGEN-PRESENTING CELLS; ENDOTHELIAL GROWTH-FACTOR; HUMAN DENDRITIC CELLS; REGULATORY T-CELLS; CD40-DEFICIENT MICE; IMMUNE-RESPONSES; NAIVE PRECURSORS; TUMOR-ANTIGENS; IN-VIVO; LYMPHOCYTES Multiple languages Hematology; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13937