Universität zu Köln

Mallmann, Michael R., Reutter, Heiko, Mack-Detlefsen, Birte, Gottschalk, Ingo, Geipel, Annegret, Berg, Christoph, Boemers, Thomas M. and Gembruch, Ulrich ORCID: 0000-0001-8284-4669 (2019). Prenatal Diagnosis of Hydro(metro)colpos: A Series of 20 Cases. Fetal Diagn. Ther., 45 (1). S. 62 - 69. BASEL: KARGER. ISSN 1421-9964

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Abstract

Background: Hydrocolpos and hydrometrocolpos are rare malformations caused by accumulation of secretion due to congenital obstruction of the vagina. Hydro(metro)colpos may be isolated or can be combined with other malformations as part of a syndromic disorder. We report on a series of 20 cases with hydro(metro) colpos diagnosed prenatally, delineate the differential diagnoses, and illustrate the spectrum of associated malformations. Subjects and Methods: This was a retrospective study involving 20 fetuses with hydro(metro) colpos at two large tertiary referral centers in Germany over an 18-year period (2000-2017). Results: The median diagnosis was made at 30(+4) weeks of gestation, the earliest at 20(+6) weeks, the latest at 37(+2) weeks. All 20 fetuses presented with the typical cystic structure behind the fetal bladder. Additional malformations included urogenital malformations, hexadactyly, and heart defects. Postnatal fol-low-up revealed that hydro(metro)colpos was associated with anorectal malformation in 11/20 fetuses, McKusick-Kaufman syndrome or Bardet-Biedl syndrome in 4/20 fetuses, Mayer-Rokitansky-Kuster-Hauser syndrome in 3/20 fetuses, and Herlyn-Werner-Wunderlich syndrome in 1/20. In 1 fetus pressure from an intraabdominal teratoma resulted in prenatal hydro(metro) colpos. Conclusion: Hydro(metro) colpos is a rare prenatal sonographic feature. Multidisciplinary prenatal counseling should include all potential syndromes that can present with hydro(metro) colpos in the prenatal setting. (c) 2018 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mallmann, Michael R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reutter, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Mack-Detlefsen, Birte UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottschalk, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Boemers, Thomas M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140054
DOI:	10.1159/000486781
Journal or Publication Title:	Fetal Diagn. Ther.
Volume:	45
Number:	1
Page Range:	S. 62 - 69
Date:	2019
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1421-9964
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MCKUSICK-KAUFMAN-SYNDROME; BARDET-BIEDL; HYDROMETROCOLPOS SECONDARY; FETAL; MALFORMATIONS; OVERLAP; ANUS Multiple languages Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14005