Universität zu Köln

Mirza, Nora ORCID: 0000-0001-9808-086X, Sowa, Anna S., Lautz, Katja and Kufer, Thomas A. (2019). NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses. J. Immunol., 202 (1). S. 218 - 228. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

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Abstract

NOD-like receptors (NLR) are critical regulators of innate immune signaling. The NLR family consists of 22 human proteins with a conserved structure containing a central oligomerization NACHT domain, an N-terminal interaction domain, and a variable number of C-terminal leucine-rich repeats. Most NLR proteins function as cytosolic pattern recognition receptors with activation of downstream inflammasome signaling, NF-kappa B, or MAPK activation. Although NLRP10 is the only NLR protein lacking the leucine rich repeats, it has been implicated in multiple immune pathways, including the regulation of inflammatory responses toward Leishmania major and Shigella flexneri infection. In this study, we identify Abin-1, a negative regulator of NF-kappa B, as an interaction partner of NLRP10 that binds to the NACHT domain of NLRP10. Using S. flexneri as an infection model in human epithelial cells, our work reveals a novel function of NLRP10 in destabilizing Abin-1, resulting in enhanced proinflammatory signaling. Our data give insight into the molecular mechanism underlying the function of NLRP10 in innate immune responses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mirza, Nora UNSPECIFIED orcid.org/0000-0001-9808-086X UNSPECIFIED Sowa, Anna S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lautz, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kufer, Thomas A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140601
DOI:	10.4049/jimmunol.1800334
Journal or Publication Title:	J. Immunol.
Volume:	202
Number:	1
Page Range:	S. 218 - 228
Date:	2019
Publisher:	AMER ASSOC IMMUNOLOGISTS
Place of Publication:	BETHESDA
ISSN:	1550-6606
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; A20-BINDING INHIBITOR; SHIGELLA-FLEXNERI; ACTIVATION; PROTEIN; BINDING; IMMUNITY; A20; EXPRESSION; SHARPIN Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14060