Universität zu Köln

Beielstein, Anna C. and Pallasch, Christian P. ORCID: 0000-0001-5675-6905 (2019). Tumor Metabolism as a Regulator of Tumor-Host Interactions in the B-Cell Lymphoma Microenvironment-Fueling Progression and Novel Brakes for Therapy. Int. J. Mol. Sci., 20 (17). BASEL: MDPI. ISSN 1422-0067

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Abstract

Tumor metabolism and its specific alterations have become an integral part of understanding functional alterations leading to malignant transformation and maintaining cancer progression. Here, we review the metabolic changes in B-cell neoplasia, focusing on the effects of tumor metabolism on the tumor microenvironment (TME). Particularly, innate and adaptive immune responses are regulated by metabolites in the TME such as lactate. With steadily increasing therapeutic options implicating or utilizing the TME, it has become essential to address the metabolic alterations in B-cell malignancy for therapeutic approaches. In this review, we discuss metabolic alterations of B-cell lymphoma, consequences for currently used therapy regimens, and novel approaches specifically targeting metabolism in the TME.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Beielstein, Anna C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pallasch, Christian P. UNSPECIFIED orcid.org/0000-0001-5675-6905 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142127
DOI:	10.3390/ijms20174158
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	20
Number:	17
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; ARYL-HYDROCARBON RECEPTOR; INDOLEAMINE 2,3-DIOXYGENASE 1; ACID DERIVATIVE AIC-47; MEMORY T-CELLS; GLUCOSE-METABOLISM; MYELOID-LEUKEMIA; C-MYC; GLUTAMINE-METABOLISM; LACTATE-DEHYDROGENASE Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14212