Universität zu Köln

Marchi, Jacopo, Laessig, Michael, Mora, Thierry and Walczak, Aleksandra M. (2019). Multi-Lineage Evolution in Viral Populations Driven by Host Immune Systems. Pathogens, 8 (3). BASEL: MDPI. ISSN 2076-0817

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Abstract

Viruses evolve in the background of host immune systems that exert selective pressure and drive viral evolutionary trajectories. This interaction leads to different evolutionary patterns in antigenic space. Examples observed in nature include the effectively one-dimensional escape characteristic of influenza A and the prolonged coexistence of lineages in influenza B. Here, we use an evolutionary model for viruses in the presence of immune host systems with finite memory to obtain a phase diagram of evolutionary patterns in a two-dimensional antigenic space. We find that, for small effective mutation rates and mutation jump ranges, a single lineage is the only stable solution. Large effective mutation rates combined with large mutational jumps in antigenic space lead to multiple stably co-existing lineages over prolonged evolutionary periods. These results combined with observations from data constrain the parameter regimes for the adaptation of viruses, including influenza.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marchi, Jacopo UNSPECIFIED UNSPECIFIED UNSPECIFIED Laessig, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Mora, Thierry UNSPECIFIED UNSPECIFIED UNSPECIFIED Walczak, Aleksandra M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142425
DOI:	10.3390/pathogens8030115
Journal or Publication Title:	Pathogens
Volume:	8
Number:	3
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-0817
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DYNAMICS; SELECTION; VIRUS Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14242