Universität zu Köln

Tichelbaecker, T., Dumitrescu, D., Gerhardt, F., Stern, D., Wissmueller, M., Adam, M., Schmidt, T., Frerker, C., Pfister, R., Halbach, M., Baldus, S. and Rosenkranz, S. (2019). Pulmonary hypertension and valvular heart disease. Herz, 44 (6). S. 491 - 502. MUNICH: URBAN & VOGEL. ISSN 1615-6692

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Abstract

Pulmonary hypertension (PH) is an important contributor to morbidity and mortality in patients with left-sided heart disease, including valvular heart disease. In this context, elevated left atrial pressure primarily leads to the development of post-capillary PH. Despite the fact that repair of left-sided valvular heart disease by surgical or interventional approaches will improve PH, recent studies have highlighted that PH (pre- or post-interventional) remains an important predictor of long-term outcome. Here, we review the current knowledge on PH in valvular heart disease taking into account new hemodynamic PH definitions, and the distinction between post- and pre-capillary components of PH. A specific focus is on the precise characterization of hemodynamics and cardiopulmonary interaction, and on potential strategies for the management of residual PH after mitral or aortic valve interventions. In addition, we highlight the clinical significance of tricuspid regurgitation, which may occur as a primary condition or as a consequence of PH and right heart dilatation (functional). In this context, proper patient selection for potential tricuspid valve interventions is crucial. Finally, the article highlights gaps in evidence, and points toward future perspectives.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tichelbaecker, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumitrescu, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerhardt, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stern, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wissmueller, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Frerker, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Halbach, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142942
DOI:	10.1007/s00059-019-4823-6
Journal or Publication Title:	Herz
Volume:	44
Number:	6
Page Range:	S. 491 - 502
Date:	2019
Publisher:	URBAN & VOGEL
Place of Publication:	MUNICH
ISSN:	1615-6692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AORTIC-VALVE-REPLACEMENT; VASCULAR-RESISTANCE; TRICUSPID REGURGITATION; PROGNOSTIC IMPLICATIONS; HEMODYNAMIC ASSESSMENT; ARTERIAL-HYPERTENSION; RISK-FACTORS; TRANSCATHETER; SURGERY; PRESSURE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14294