Universität zu Köln

Wuelfing, C., Boegemann, M., Goebell, P. J., Hammerer, P., Machtens, S., Pfister, D., Schwentner, C., Steuber, T., von Amsberg, G. and Schostak, M. (2019). Treatment situation in metastastic Castration Naive Prostate Cancer (mCRPC) and the implications on clinical routine. Urologe, 58 (9). S. 1066 - 1073. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

There is an ongoing change of paradigm in the treatment of metastatic prostate cancer (mPC). Taxan-based chemotherapy demonstrated a prolonged survival of patients in several randomized phase III trials. This is true in the situation of metastatic castration-resistent prostate cancer (mCRPC) as well as in the hormone-naive stage (metastatic castration-naive PC [mCNPC]). In patients with mCNPC, treatment with docetaxel in combination with androgen deprivation therapy (ADT) prolonged the median total survival time by 15 months in comparison to ADT alone. Comparable results were obtained by the endocrine combination treatment with ADT/abiraterone. With the current data in mind it seems to be useful to discuss the value of early combination therapy with ADT/docetaxel or ADT/abiraterone as well as the impact on further treatment options in the mCRPC setting and to define criteria for treatment decisions in clinical practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wuelfing, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boegemann, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goebell, P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammerer, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Machtens, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwentner, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steuber, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Amsberg, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schostak, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143387
DOI:	10.1007/s00120-019-0925-2
Journal or Publication Title:	Urologe
Volume:	58
Number:	9
Page Range:	S. 1066 - 1073
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POST-HOC ANALYSIS; ABIRATERONE ACETATE; OPEN-LABEL; DOCETAXEL; THERAPY; MEN; CABAZITAXEL; SURVIVAL Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14338