Universität zu Köln

Ernst, Thomas Michael, Brol, Anna Evelina, Gratz, Marcel, Ritter, Christoph, Bingel, Ulrike, Schlamann, Marc, Maderwald, Stefan, Quick, Harald H., Merz, Christian Josef and Timmann, Dagmar (2019). The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm. eLife, 8. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Prediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance imaging. An event-related design allowed us to separate cerebellar fMRI signals related to the visual conditioned stimulus (CS) from signals related to the subsequent unconditioned stimulus (US; an aversive electric shock). We found significant activation of cerebellar lobules Crus I and VI bilaterally related to the CS+ compared to the CS-. Most importantly, significant activation of lobules Crus I and VI was also present during the unexpected omission of the US in unreinforced CS+ acquisition trials. This activation disappeared during extinction when US omission became expected. These findings provide evidence that the cerebellum has to be added to the neural network processing predictions and prediction errors in the emotional domain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ernst, Thomas Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Brol, Anna Evelina UNSPECIFIED UNSPECIFIED UNSPECIFIED Gratz, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritter, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Bingel, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Maderwald, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Quick, Harald H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merz, Christian Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmann, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143797
DOI:	10.7554/eLife.46831
Journal or Publication Title:	eLife
Volume:	8
Date:	2019
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEART-RATE; PREFRONTAL CORTEX; NEURONAL CIRCUITS; NEURAL SUBSTRATE; INTERNAL-MODELS; WORKING-MEMORY; BASAL GANGLIA; 7T FMRI; BRAIN; PROJECTIONS Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14379