Universität zu Köln

Grau, Marijke, Jerke, Max, Nader, Elie ORCID: 0000-0002-6054-2456, Schenk, Alexander, Renoux, Celine, Collins, Bianca, Dietz, Thomas, Bizjak, Daniel Alexander, Joly, Philippe, Bloch, Wilhelm, Connes, Philippe ORCID: 0000-0002-9232-0268 and Prokop, Aram (2019). Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients. Sci Rep, 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subjects reached the first ventilatory threshold (VT1). Blood was sampled at rest and at VT1. At rest, free haemoglobin level was higher and RBC count, haemoglobin and haematocrit were lower in SCA compared to AA. RBC deformability was lower in SCA. Exercise had no effect on the tested parameters. RBC NO level was higher in SCA compared to AA at rest and significantly decreased after exercise in SCA. This might be related to a reduction in RBC-NO synthase (RBC-NOS) activation which was only observed in SCA after exercise. Free radical levels were higher in SCA at rest but concentration was not affected by exercise. Marker for lipid peroxidation and antioxidative capacity were similar in SCA and AA and not affected by exercise. In conclusion, a single acute submaximal bout of exercise has no deleterious effects on RBC deformability or oxidative stress markers in SCA, and seems to modulate RBC-NOS signalling pathway.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grau, Marijke UNSPECIFIED UNSPECIFIED UNSPECIFIED Jerke, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Nader, Elie UNSPECIFIED orcid.org/0000-0002-6054-2456 UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Renoux, Celine UNSPECIFIED UNSPECIFIED UNSPECIFIED Collins, Bianca UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietz, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bizjak, Daniel Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Joly, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Connes, Philippe UNSPECIFIED orcid.org/0000-0002-9232-0268 UNSPECIFIED Prokop, Aram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144348
DOI:	10.1038/s41598-019-48364-1
Journal or Publication Title:	Sci Rep
Volume:	9
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MODERATE ENDURANCE EXERCISE; OXIDATIVE STRESS; PHYSICAL-FITNESS; BLOOD; HEMOGLOBIN; HEMOLYSIS; CHEMILUMINESCENCE; PATHOPHYSIOLOGY; ERYTHROCYTES; HEMORHEOLOGY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14434