Universität zu Köln

Lee, Hyun Ju, Noormohammadi, Alireza, Koyuncu, Seda, Calculli, Giuseppe, Simic, Milos S., Herholz, Marija, Trifunovic, Aleksandra ORCID: 0000-0002-5472-3517 and Vilchez, David ORCID: 0000-0002-0801-0743 (2019). Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans. Nat. Metab., 1 (8). S. 790 - 811. LONDON: NATURE PUBLISHING GROUP. ISSN 2522-5812

Full text not available from this repository.

Abstract

A moderate reduction in body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germline fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germline stem cells (GSCs) in Caenorhabditis elegans, a process modulated by thermosensory neurons. Notably, robust self-renewal of adult GSCs delays reproductive ageing and is required for extended lifespan at cold temperatures (10 degrees C, 15 degrees C). These cells release prostaglandin E2 (PGE2) to induce cbs-1 expression in the intestine, increasing the somatic production of hydrogen sulfide, a gaseous signalling molecule that prolongs lifespan. Loss of adult GSCs reduces intestinal cbs-1 expression and cold-induced longevity, whereas application of exogenous PGE2 rescues these phenotypes. Importantly, tissue-specific intestinal overexpression of cbs-1 mimics cold-temperature conditions and extends longevity even at warm temperatures (25 degrees C). Thus, our results indicate that GSCs communicate with somatic tissues to coordinate extended reproductive capacity with longevity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lee, Hyun Ju UNSPECIFIED UNSPECIFIED UNSPECIFIED Noormohammadi, Alireza UNSPECIFIED UNSPECIFIED UNSPECIFIED Koyuncu, Seda UNSPECIFIED UNSPECIFIED UNSPECIFIED Calculli, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Simic, Milos S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herholz, Marija UNSPECIFIED UNSPECIFIED UNSPECIFIED Trifunovic, Aleksandra UNSPECIFIED orcid.org/0000-0002-5472-3517 UNSPECIFIED Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-144892
DOI:	10.1038/s42255-019-0097-9
Journal or Publication Title:	Nat. Metab.
Volume:	1
Number:	8
Page Range:	S. 790 - 811
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2522-5812
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE-SPAN; C-ELEGANS; LONGEVITY; TEMPERATURE; GENE; GROWTH; LINE; SEX; RNA; SPERMATOGENESIS Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14489