Universität zu Köln

Strizek, Brigitte ORCID: 0000-0003-3625-7097, Zamprakou, Aikaterini, Gottschalk, Ingo, Roethlisberger, Maria, Hellmund, Astrid, Mueller, Andreas, Gembruch, Ulrich ORCID: 0000-0001-8284-4669, Geipel, Annegret and Berg, Christoph (2019). Prenatal Diagnosis of Agenesis of Ductus Venosus: A Retrospective Study of Anatomic Variants, Associated Anomalies and Impact on Postnatal Outcome. Ultraschall Med., 40 (3). S. 333 - 340. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8782

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Abstract

Purpose To assess the anatomic variants, associated anomalies and postnatal outcome of fetuses with a prenatally diagnosed agenesis of ductus venosus (ADV). Materials and Methods Retrospective study of 119 cases with agenesis of ductus venosus diagnosed by prenatal ultrasound in two tertiary referral centers from 2006 to 2014. The type and location of the umbilical venous drainage site was noted. Charts were reviewed for associated structural or chromosomal anomalies, pregnancy outcome and postnatal course. Results In 24 cases (20.2%) ADV was an isolated finding, while 95 cases (79.8%) had associated anomalies. We identified 84 cases (70.6%) with intrahepatic and 35 cases (29.4%) with extrahepatic drainage of the umbilical vein. 58.8% of neonates were alive at follow-up.There was no statistical association between drainage site and associated anomalies or outcome. Postnatal outcome was determined by the presence and severity of associated anomalies. There was no adverse outcome in the isolated group related to ADV. Overall, there were 6 persistent portosystemic shunts, 3 of them with a spontaneous closure, and one total agenesis of the portal venous system with lethal outcome. Conclusion Postnatal outcome in cases with ADV mainly depends on the presence of associated anomalies. In isolated cases the prognosis is generally good, but neonates with a prenatally diagnosed portosystemic shunt should be followed until its occlusion. Portal venous system agenesis is rare but should be ruled out on prenatal ultrasound.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Strizek, Brigitte UNSPECIFIED orcid.org/0000-0003-3625-7097 UNSPECIFIED Zamprakou, Aikaterini UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottschalk, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Roethlisberger, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmund, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-146040
DOI:	10.1055/s-0043-115109
Journal or Publication Title:	Ultraschall Med.
Volume:	40
Number:	3
Page Range:	S. 333 - 340
Date:	2019
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-8782
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-UTERO CLASSIFICATION; FETAL VENOUS SYSTEM; ULTRASOUND EVALUATION; VEINS; DRAINAGE; ABSENCE; SHUNTS Multiple languages Acoustics; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14604