Universität zu Köln

Singh, Sumit Randhir, Matet, Alexandre ORCID: 0000-0002-9721-777X, van Dijk, Elon H. C., Daruich, Alejandra, Fauser, Sascha, Yzer, Suzanne, Peiretti, Enrico ORCID: 0000-0003-1088-0163, Sivaprasad, Sobha, Lotery, Andrew J., Boon, Camiel J. F., Behar-Cohen, Francine, Freund, K. Bailey ORCID: 0000-0002-7888-9773 and Chhablani, Jay (2019). Discrepancy in current central serous chorioretinopathy classification. Br. J. Ophthalmol., 103 (6). S. 737 - 743. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079

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Abstract

Aim To report the discordance in central serous chorioretinopathy (CSCR) classification among practising retina specialists. Methods The study conducted was a multicentre survey. Multimodal retinal images along with relevant clinical details of 100 cases diagnosed as CSCR (from six centres) were circulated among six retina specialists across the globe. The image sets included colour fundus photographs, fundus autofluorescence images, optical coherence tomography b-scans, fluorescein and indocyanine green angiography of the study and fellow eyes. The graders were asked to classify the disease of study eye, according to their own criteria. The graders were masked to the responses of other graders. The final analysis of the pooled response data was done based on the diagnosis of study eye only. The main outcome measure was degree of agreement between six independent observers using Fleiss Kappa statistics. Results Grading for 100 eyes of 100 patients (men, 93%) was included in the analysis. 20 patients had a history of steroid use. The graders provided 36 different terms to classify the disease, with poor agreement among graders (Fleiss Kappa=0.134). The consistency in diagnosing acute CSCR was statistically higher than for either chronic (p=0.012) or recurrent CSCR (p<0.0001). When collapsing descriptors into six main terms, agreement remained poor (Fleiss Kappa=0.218). Conclusion The high discordance among experienced retina specialists in describing CSCR clinical subtypes is highlighted. The current work demonstrates the limitations of current empirical CSCR classification methods and the need for a more objective and refined system to bring uniformity in diagnosis and prognostication of the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Singh, Sumit Randhir UNSPECIFIED UNSPECIFIED UNSPECIFIED Matet, Alexandre UNSPECIFIED orcid.org/0000-0002-9721-777X UNSPECIFIED van Dijk, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Daruich, Alejandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Yzer, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Peiretti, Enrico UNSPECIFIED orcid.org/0000-0003-1088-0163 UNSPECIFIED Sivaprasad, Sobha UNSPECIFIED UNSPECIFIED UNSPECIFIED Lotery, Andrew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Behar-Cohen, Francine UNSPECIFIED UNSPECIFIED UNSPECIFIED Freund, K. Bailey UNSPECIFIED orcid.org/0000-0002-7888-9773 UNSPECIFIED Chhablani, Jay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-146322
DOI:	10.1136/bjophthalmol-2018-312435
Journal or Publication Title:	Br. J. Ophthalmol.
Volume:	103
Number:	6
Page Range:	S. 737 - 743
Date:	2019
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2079
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDOCYANINE GREEN ANGIOGRAPHY; NEOVASCULARIZATION; PATHOPHYSIOLOGY; DETACHMENTS; SECONDARY; FEATURES; UPDATE; EYES Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14632