Universität zu Köln

Esche, Jonas, Shi, Lijie, Hartmann, Michaela F., Schoenau, Eckhard, Wudy, Stefan A. and Remer, Thomas (2019). Glucocorticoids and Body Fat Inversely Associate With Bone Marrow Density of the Distal Radius in Healthy Youths. J. Clin. Endocrinol. Metab., 104 (6). S. 2250 - 2257. WASHINGTON: ENDOCRINE SOC. ISSN 1945-7197

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Abstract

Context: Elevated bone marrow adipose tissue (BMAT) is associated with lower bone quality, higher fracture rates, and an unfavorable overall metabolic profile. Apart from age, particularly gluco-corticoids (GC), body fat, and diet are discussed to influence BMAT. We hypothesized that already in healthy youths, higher fat intake, higher fat mass index (FMI), and higher GC secretion, still within the normal range, may associate with increased BMAT. Design: In a subsample of healthy 6- to 18-year-old participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed Study, peripheral quantitative CT of the nondominant proximal forearm was used to determine bone marrow density of the distal radius as an inverse surrogate parameter for BMAT. In those participants (n = 172) who had collected two, 24-hour urines within around one year before bone measurement, major urinary GC metabolites were measured by gas chromatography-mass spectrometry and summed up to assess daily adrenal GC secretion (Sigma C21). Dietary intake was assessed by 3-day weighed dietary records. FMI was anthropometrically calculated. Separate multiple linear regression models were used to analyze the relationships of Sigma C21, FMI, and fat intake with BMAT. Results: After controlling for confounders, such as age, energy intake, and forearm muscle area, Sigma C21 (beta= -0.042) and FMI (beta = -0.002) showed inverse relationships with bone marrow density (P < 0.05), whereas fat intake did not associate significantly. Conclusion: Our results indicate that already a moderately elevated GC secretion and higher body fatness during adolescence may adversely impact BMAT, an indicator for long-term bone health.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Esche, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Lijie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Michaela F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Wudy, Stefan A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Remer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-146645
DOI:	10.1210/jc.2018-02108
Journal or Publication Title:	J. Clin. Endocrinol. Metab.
Volume:	104
Number:	6
Page Range:	S. 2250 - 2257
Date:	2019
Publisher:	ENDOCRINE SOC
Place of Publication:	WASHINGTON
ISSN:	1945-7197
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADIPOSE-TISSUE; MINERAL DENSITY; CORTISOL SECRETION; PROXIMAL RADIUS; CHILDREN; MASS; OSTEOPOROSIS; OSTEOBLASTS; METABOLISM; MECHANISMS Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14664