Universität zu Köln

Schieber, Katharina, Niecke, Alexander, Geiser, Franziska, Erim, Yesim, Bergelt, Corinna ORCID: 0000-0003-1413-1872, Buttner-Teleaga, Antje, Maatouk, Imad, Stein, Barbara, Teufel, Martin, Wickert, Martin, Wuensch, Alexander and Weis, Joachim (2019). The course of cancer-related insomnia: don't expect it to disappear after cancer treatment. Sleep Med., 58. S. 107 - 114. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1878-5506

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Abstract

Objective: The study aimed to examine the 12-month course of cancer-related insomnia (CRI) and to identify possible predictors for the prevalence and persistence of CRI. Methods: This longitudinal multicenter study included N = 405 patients with cancer (56% females, mean age: 58.6 years). CRI was measured by the Insomnia Severity Index (ISI). Socio-demographic and clinical data, as well as psychological parameters (Distress Thermometer, PHQ-9, GAD-7, and EORTC-Fatigue), were assessed at baseline (T1) and 12 months later (T2). Results: In our sample, a high prevalence of relevant insomnia symptoms (49.4%, ISI > 7) was found, while a clinical insomnia diagnosis was verified in 12.8% (ISI > 14). When insomnia was present at T1, this problem was persistent after one year in 64%. At T2, however, significantly more women suffered from insomnia symptoms (53.3% women vs. 39.3% men; p = 0.003). Insomnia was associated with many clinical and psychological parameters, especially with fatigue (r = 0.5). Multiple regression analysis revealed that, in women, only insomnia at T1 was a significant predictor for insomnia at T2 (R-2 = 0.40; F(5) = 12.5; p < 0.001), whereas in men insomnia, depressive symptoms and the use of psychotropic drugs at T1 predicted the extent of insomnia at T2 (R-2 = 0.28; F(7) = 9.5; p < 0.001). In all participants, levels of distress, depression, and anxiety decreased from T1 to T2 (p's < 0.016). Conclusion: Insomnia is a common disorder in cancer patients. Although medical and psychological parameters improved during the 12-month course of cancer treatment, our results show that insomnia is highly persistent, especially in women. This indicates that adequate support for those affected is needed. (C) 2019 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schieber, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Niecke, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Geiser, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Erim, Yesim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergelt, Corinna UNSPECIFIED orcid.org/0000-0003-1413-1872 UNSPECIFIED Buttner-Teleaga, Antje UNSPECIFIED UNSPECIFIED UNSPECIFIED Maatouk, Imad UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Teufel, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickert, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuensch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Weis, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-146663
DOI:	10.1016/j.sleep.2019.02.018
Journal or Publication Title:	Sleep Med.
Volume:	58
Page Range:	S. 107 - 114
Date:	2019
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1878-5506
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; SLEEP DISTURBANCES; SEVERITY INDEX; DEPRESSION; VALIDATION; DISORDERS; SURVIVORS; SYMPTOMS; ADULTS; RISK Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14666