Wittekindt, Claus, Wagner, Steffen, Bushnak, Ayman, Prigge, Elena-Sophie, Doeberitz, Magnus von Knebel, Wuerdemann, Nora, Bernhardt, Katharina, Pons-Kuehnemann, Joern, Maulbecker-Armstrong, Catharina and Klussmann, Jens Peter (2019). Increasing Incidence rates of Oropharyngeal Squamous Cell Carcinoma in Germany and Significance of Disease Burden Attributed to Human Papillomavirus. Cancer Prev. Res., 12 (6). S. 375 - 383. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1940-6215

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Abstract

Increasing incidences of head and neck cancers and rising proportions of these associated with human papillomavirus (HPV), especially in the oropharynx, have been reported in international studies. So far, the trends and contribution of HPV to the number of newly diagnosed cases of oropharyngeal squamous cell carcinomas (OPSCC) in Germany are uncertain. We investigated HPV association and incidence rates in a cohort of consecutively included patients with OPSCC in Giessen 2000-2017, and compared our results with regional (Giessen and the federal state of Hesse), national (Germany), and international (United States) databases. Regional data show a significant increase in the overall incidence rates of oropharyngeal cancers and in the incidence of HPV-associated cancers of the subsites tonsils and oropharynx, where- as other oropharyngeal subsites show no significant change. Analysis of national databases shows a significant incidence increase in Germany and in the United States. The rise in incidence is predominantly attributable to male patients in the US population, whereas in Germany rising OPSCC incidence is more associated with females. There is a significant elevation of OPSCC incidence rates in Germany, which corresponds to the recognized incidence increase of HPV-related oropharyngeal cancers based on experimental data from consecutively included patients of our cohort. Our investigation shows different patterns of this increase in Germany and in the United States, which demonstrates spatial heterogeneity and the need for population-based investigations regarding the role of HPV in oropharyngeal cancer.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wittekindt, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bushnak, AymanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prigge, Elena-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doeberitz, Magnus von KnebelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuerdemann, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernhardt, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pons-Kuehnemann, JoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maulbecker-Armstrong, CatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klussmann, Jens PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-146682
DOI: 10.1158/1940-6207.CAPR-19-0098
Journal or Publication Title: Cancer Prev. Res.
Volume: 12
Number: 6
Page Range: S. 375 - 383
Date: 2019
Publisher: AMER ASSOC CANCER RESEARCH
Place of Publication: PHILADELPHIA
ISSN: 1940-6215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
UNITED-STATES; ORAL-CAVITY; CANCER; HEAD; ASSOCIATION; PREVALENCE; SURVIVAL; EPIDEMIOLOGY; RISKMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14668

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