Ebrahimi, Ardalan ORCID: 0000-0002-5433-3965, Gil, Ziv, Amit, Moran, Yen, Tzu-Chen, Liao, Chun-ta, Chaturvedi, Pankaj, Agarwal, Jai Prakash, Kowalski, Luiz P., Kohler, Hugo F., Kreppel, Matthias, Cernea, Claudio R., Brandao, Jason, Bachar, Gideon, Villaret, Andrea Bolzoni, Fliss, Dan M., Fridman, Eran, Robbins, Kevin Thomas, Shah, Jatin P., Patel, Snehal G. and Clark, Jonathan R. (2019). Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Study. Head Neck-J. Sci. Spec. Head Neck, 41 (6). S. 1935 - 1943. HOBOKEN: WILEY. ISSN 1097-0347

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Abstract

Background We aimed to investigate whether depth of invasion (DOI) should be an independent indication for postoperative radiotherapy (PORT) in small oral squamous cell carcinomas (SCC). Methods Retrospective analysis of DOI (<5, 5 to <10, >= 10 mm) and disease-specific survival (DSS) in a multi-institutional international cohort of 1409 patients with oral SCC <= 4 cm in size treated between 1990-2011. Results In patients without other adverse factors (nodal metastases; close [<5 mm] or involved margins), there was no association between DOI and DSS, with an excellent prognosis irrespective of depth. In the absence of PORT, the 5-year disease-specific mortality was 10% with DOI >= 10 mm, 8% with DOI 5-10 mm, and 6% with DOI <5 mm (P = .169), yielding an absolute risk difference of only 4%. Conclusion The deterioration in prognosis with increasing DOI largely reflects an association with other adverse features. In the absence of these, depth alone should not be an indication for PORT outside a clinical trial.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ebrahimi, ArdalanUNSPECIFIEDorcid.org/0000-0002-5433-3965UNSPECIFIED
Gil, ZivUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amit, MoranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yen, Tzu-ChenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liao, Chun-taUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaturvedi, PankajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agarwal, Jai PrakashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kowalski, Luiz P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohler, Hugo F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreppel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cernea, Claudio R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandao, JasonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bachar, GideonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villaret, Andrea BolzoniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliss, Dan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fridman, EranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robbins, Kevin ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah, Jatin P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, Snehal G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clark, Jonathan R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-146958
DOI: 10.1002/hed.25633
Journal or Publication Title: Head Neck-J. Sci. Spec. Head Neck
Volume: 41
Number: 6
Page Range: S. 1935 - 1943
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0347
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TUMOR THICKNESS; PROGNOSTIC-SIGNIFICANCE; NECK DISSECTION; TONGUE; CANCER; SURVIVAL; CAVITY; STAGE; RISK; PATTERNMultiple languages
Otorhinolaryngology; SurgeryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14695

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