Universität zu Köln

Benz, M. R., Ehren, R., Toenshoff, B. and Weber, L. T. (2019). Nephrotic syndrome in childhood. Mon.schr. Kinderheilkd., 167 (6). S. 488 - 500. NEW YORK: SPRINGER. ISSN 1433-0474

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Abstract

Despite fulfilling the criteria for an orphan disease, idiopathic nephrotic syndrome in children is the most frequent glomerular disease in this age group. Nephrotic syndrome is defined by the detection of a high proteinuria (>1g/m(2) body surface area daily) and hypoalbuminemia (<2,5 g/dl). Edema is also mostly present, especially at the first manifestation. Nephrotic syndrome in children is a heterogeneous disease with respect to age of onset, etiology, histological alterations and response to a standard treatment of glucocorticoids. This diversity strongly influences both the differential diagnostic approach and the treatment. As the prognosis of steroid-sensitive nephrotic syndrome with respect to renal function is generally good, not only the efficacy of an immunosuppressive medication but also the side effect profiles of different immunosuppressive regimens should be kept in mind for treatment planning and optimization.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Benz, M. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehren, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toenshoff, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, L. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-147015
DOI:	10.1007/s00112-019-0677-5
Journal or Publication Title:	Mon.schr. Kinderheilkd.
Volume:	167
Number:	6
Page Range:	S. 488 - 500
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0474
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYCOPHENOLATE-MOFETIL; CHILDREN; ONSET; RISK; CYCLOSPORINE; MULTICENTER; THERAPY; CORTICOSTEROIDS; PREDNISOLONE; MANAGEMENT Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14701