Universität zu Köln

Truse, Richard ORCID: 0000-0001-6650-5800, Voss, Fabian, Herminghaus, Anna, Schulz, Jan, Weber, Andreas P. M., Mettler-Altmann, Tabea, Bauer, Inge, Picker, Olaf and Vollmer, Christian (2019). Local gastric RAAS inhibition improves gastric microvascular perfusion in dogs. J. Endocrinol., 241 (3). S. 235 - 248. BRISTOL: BIOSCIENTIFICA LTD. ISSN 1479-6805

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Abstract

During circulatory shock, gastrointestinal microcirculation is impaired, especially via activation of the renin-angiotensin-aldosterone system. Therefore, inhibition of the renin-angiotensin-aldosterone system might be beneficial in maintaining splanchnic microcirculation. The aim of this study was to analyze whether locally applied losartan influences gastric mucosal perfusion (mu flow, mu velo) and oxygenation (mu HbO(2)) without systemic hemodynamic changes. In repetitive experiments six anesthetized dogs received 30 mg losartan topically on the oral and gastric mucosa during normovolemia and hemorrhage (-20% blood volume). Microcirculatory variables were measured with reflectance spectrometry, laser Doppler flowmetry and incident dark field imaging. Transpulmonary thermodilution and pulse contour analysis were used to measure systemic hemodynamic variables. Gastric barrier function was assessed via differential absorption of inert sugars. During normovolemia, losartan increased gastric mu flow from 99 +/- 6 aU to 147 +/- 17 aU and mu velo from 17 +/- 1 aU to 19 +/- 1 all. During hemorrhage, losartan did not improve mu flow. mu velo decreased from 17 +/- 1 aU to 14 +/- 1 aU in the control group. Application of losartan did not significantly alter mu velo (16 +/- 1 aU) compared to the control group and to baseline levels (17 +/- 1 aU). No effects of topical losartan on macrohemodynamic variables or microcirculatory oxygenation were detected. Gastric microcirculatory perfusion is at least partly regulated by local angiotensin receptors. Topical application of losartan improves local perfusion via vasodilation without significant effects on systemic hemodynamics. During mild hemorrhage losartan had minor effects on regional perfusion, probably because of a pronounced upstream vasoconstriction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Truse, Richard UNSPECIFIED orcid.org/0000-0001-6650-5800 UNSPECIFIED Voss, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Herminghaus, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Andreas P. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mettler-Altmann, Tabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Inge UNSPECIFIED UNSPECIFIED UNSPECIFIED Picker, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollmer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-147267
DOI:	10.1530/JOE-19-0030
Journal or Publication Title:	J. Endocrinol.
Volume:	241
Number:	3
Page Range:	S. 235 - 248
Date:	2019
Publisher:	BIOSCIENTIFICA LTD
Place of Publication:	BRISTOL
ISSN:	1479-6805
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANGIOTENSIN-II RECEPTOR; NITRIC-OXIDE; EXERCISE CAPACITY; OXYGEN-SATURATION; HEMORRHAGIC-SHOCK; TISSUE PERFUSION; BARRIER FUNCTION; SMALL-INTESTINE; BLOOD-FLOW; BLOCKADE Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14726