Universität zu Köln

Salunkhe, G., Feige, B., Saville, C. W. N., Lancaster, T. M., Stefanou, M. E., Bender, S., Berger, A., Smyrnis, N., Biscaldi, M., Linden, D. E. J. and Klein, C. (2019). The impact of the COMT genotype and cognitive demands on facets of intra-subject variability. Brain Cogn., 132. S. 72 - 80. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2147

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Abstract

Intra-Subject Variability (ISV), a potential index of catecholaminergic regulation, is elevated in several disorders linked with altered dopamine function. ISV has typically been defined as reaction time standard deviation. However, the ex-Gaussian and spectral measures capture different aspects and may delineate different underlying sources of ISV; thus reflecting different facets of the construct. We examined the impact of factors associated with dopamine metabolism, namely, Catechol-O-Methyltransferase Val158Met (COMT) genotype and Working Memory (WM) and response-switching on ISV facets in young healthy adults. The Met allele was associated with overall increased variability. The rather exclusive sensitivity of ex-Gaussian tau to frequencies below 0.025 Hz and the quasi-periodic structure of particularly slow responses support the interpretation of tau as low frequency fluctuations of neuronal networks. Sigma, by contrast, may reflect neural noise. Regarding cognitive demands, a WM load-related increase in variability was present for all genotypes and all ISV facets. Contrastingly, ISV facets reacted differently to variations in response-switching as, across genotypes, sigma was elevated for rare target trials whereas tau was elevated for frequent standard trials, particularly for Met homozygotes. Our findings support the significant role of COMT in regulating behavioural ISV with its facetted structure and presumed underlying neural processes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Salunkhe, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feige, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saville, C. W. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lancaster, T. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stefanou, M. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyrnis, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Biscaldi, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Linden, D. E. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-147599
DOI:	10.1016/j.bandc.2019.03.002
Journal or Publication Title:	Brain Cogn.
Volume:	132
Page Range:	S. 72 - 80
Date:	2019
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2147
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REACTION-TIME VARIABILITY; INTRAINDIVIDUAL VARIABILITY; VAL(158)MET POLYMORPHISM; WORKING-MEMORY; RESPONSE-TIME; DOPAMINE; FLUCTUATIONS; SCHIZOPHRENIA; PERFORMANCE; CHILDREN Multiple languages Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14759