Wu, Wanlong, Jordan, Suzana ORCID: 0000-0002-8114-8239, Graf, Nicole, Pena, Janethe de Oliveira, Curram, John, Allanore, Yannick, Matucci-Cerinic, Marco, Pope, Janet E., Denton, Christopher P., Khanna, Dinesh, Distler, Oliver ORCID: 0000-0002-0546-8310, Matucci-Cerinic, Marco, Guiducci, Serena ORCID: 0000-0003-2722-6475, Walker, Ulrich, Jaeger, Veronika ORCID: 0000-0002-6913-0976, Bannert, Bettina, Lapadula, Giovanni ORCID: 0000-0002-8427-6092, Becvarare, Radim, Cutolo, Maurizio, Valentini, Gabriele, Siegert, Elise, Rednic, Simona, Allanore, Yannick, Montecucco, C., Carreira, Patricia E., Novak, Srdan ORCID: 0000-0001-8870-4704, Czirjak, Laszlo, Varju, Cecilia ORCID: 0000-0002-6849-9114, Chizzolini, Carlo, Allai, Daniela, Kucharz, Eugene J., Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Gabrielli, Armando, Bancel, Dominique Farge, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Hunzelmann, Nicolas, Pellerito, Raffaele, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Seidel, Matthias, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Selmi, Carlo Francesco, Tikly, Mohammed, Denisov, Lev N., Mueller-Ladner, Ulf, Engelhart, Merete, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra Maria, Mihai, Carina, Sunderkoetter, Cord, Kuhn, Annegret, Schett, Georg, Distler, Joerg, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Anne, Erler, Westhovens, Rene, De Langhe, Ellen, Lenaerts, Jan, Anic, Branimir ORCID: 0000-0003-4940-0577, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Popa, Sergei, Zenone, Thierry, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas ORCID: 0000-0003-2802-4971, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo ORCID: 0000-0002-7417-8093, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario ORCID: 0000-0002-7301-8362, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Chirieac, Rodica, Villiger, Peter, Adler, Sabine, Dan, Diana, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Del Galdo, Francesco, Venalis, Algirdas, Saketkoo, Lesley Ann, Lasky, Joseph A., Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chung, Lori, Schmeiser, Tim, Zebryk, Pawel, Riso, Nuno, Riemekasten, Gabriela, Rezus, Elena ORCID: 0000-0002-8175-2583 and Puttini, Piercarlo Sarzi
(2019).
Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort.
Ann. Rheum. Dis., 78 (5).
S. 648 - 657.
LONDON:
BMJ PUBLISHING GROUP.
ISSN 1468-2060
Full text not available from this repository.
Abstract
Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc). Methods We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) >= 7, valid mRSS at 12 +/- 3 months after baseline and >= 1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and >= 25% from baseline to 12 +/- 3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. Associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. Results Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. Survival analyses indicated that skin progressors had a significantly higher probability of FVC decline >= 10% (53.6% vs 34.4%; p<0.001) and all-cause death (15.4% vs 7.3%; p=0.003) than non-progressors. These significant associations were also found in subgroup analyses of patients with either low baseline mRSS (<= 22/51) or short disease duration (<= 15 months). In multivariable analyses, skin progression within 1 year was independently associated with FVC decline >= 10% (HR 1.79, 95% CI 1.20 to 2.65) and all-cause death (HR 2.58, 95% CI 1.31 to 5.09). Conclusions Progressive skin fibrosis within 1 year is associated with decline in lung function and worse survival in dcSSc during follow-up. These results confirm mRSS as a surrogate marker in dcSSc, which will be helpful for cohort enrichment in future trials and risk stratification in clinical practice.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Wu, Wanlong | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jordan, Suzana | UNSPECIFIED | orcid.org/0000-0002-8114-8239 | UNSPECIFIED | Graf, Nicole | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pena, Janethe de Oliveira | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Curram, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Allanore, Yannick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Matucci-Cerinic, Marco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pope, Janet E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Denton, Christopher P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Khanna, Dinesh | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Distler, Oliver | UNSPECIFIED | orcid.org/0000-0002-0546-8310 | UNSPECIFIED | Matucci-Cerinic, Marco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guiducci, Serena | UNSPECIFIED | orcid.org/0000-0003-2722-6475 | UNSPECIFIED | Walker, Ulrich | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jaeger, Veronika | UNSPECIFIED | orcid.org/0000-0002-6913-0976 | UNSPECIFIED | Bannert, Bettina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lapadula, Giovanni | UNSPECIFIED | orcid.org/0000-0002-8427-6092 | UNSPECIFIED | Becvarare, Radim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cutolo, Maurizio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Valentini, Gabriele | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Siegert, Elise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rednic, Simona | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Allanore, Yannick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Montecucco, C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Carreira, Patricia E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Novak, Srdan | UNSPECIFIED | orcid.org/0000-0001-8870-4704 | UNSPECIFIED | Czirjak, Laszlo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Varju, Cecilia | UNSPECIFIED | orcid.org/0000-0002-6849-9114 | UNSPECIFIED | Chizzolini, Carlo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Allai, Daniela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kucharz, Eugene J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cozzi, Franco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rozman, Blaz | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mallia, Carmel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gabrielli, Armando | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bancel, Dominique Farge | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Airo, Paolo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hesselstrand, Roger | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martinovic, Duska | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Balbir-Gurman, Alexandra | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Braun-Moscovici, Yolanda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hunzelmann, Nicolas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pellerito, Raffaele | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Caramaschi, Paola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Black, Carol | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Damjanov, Nemanja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Henes, Joerg | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ortiz Santamaria, Vera | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Heitmann, Stefan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seidel, Matthias | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pereira Da Silva, Jose Antonio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stamenkovic, Bojana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Selmi, Carlo Francesco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tikly, Mohammed | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Denisov, Lev N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mueller-Ladner, Ulf | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Engelhart, Merete | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hachulla, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Riccieri, Valeria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ionescu, Ruxandra Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mihai, Carina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sunderkoetter, Cord | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kuhn, Annegret | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schett, Georg | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Distler, Joerg | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meroni, Pierluigi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ingegnoli, Francesca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mouthon, Luc | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | De Keyser, Filip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Smith, Vanessa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cantatore, Francesco Paolo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Corrado, Ada | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ullman, Susanne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Iversen, Line | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pozzi, Maria Rosa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eyerich, Kilian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hein, Ruediger | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Knott, Elisabeth | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wiland, Piotr | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Szmyrka-Kaczmarek, Magdalena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sokolik, Renata | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Morgiel, Ewa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Madej, Marta | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jose Alegre-Sancho, Juan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Krummel-Lorenz, Brigitte | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Saar, Petra | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aringer, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guenther, Claudia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anne, Erler | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Westhovens, Rene | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | De Langhe, Ellen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lenaerts, Jan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anic, Branimir | UNSPECIFIED | orcid.org/0000-0003-4940-0577 | UNSPECIFIED | Baresic, Marko | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mayer, Miroslav | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Uprus, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Otsa, Kati | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yavuz, Sule | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Radominski, Sebastiao Cezar | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mueller, Carolina de Souza | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Azevedo, Valderilio Feijo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Popa, Sergei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zenone, Thierry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stebbings, Simon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Highton, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mathieu, Alessandro | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vacca, Alessandra | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stamp, Lisa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chapman, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | O'Donnell, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Solanki, Kamal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Doube, Alan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Veale, Douglas | UNSPECIFIED | orcid.org/0000-0003-2802-4971 | UNSPECIFIED | O'Rourke, Marie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Loyo, Esthela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Mengtao | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rosato, Edoardo | UNSPECIFIED | orcid.org/0000-0002-7417-8093 | UNSPECIFIED | Amoroso, Antonio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gigante, Antonietta | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Oksel, Fahrettin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yargucu, Figen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tanaseanu, Cristina-Mihaela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Popescu, Monica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dumitrascu, Alina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tiglea, Isabela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Foti, Rosario | UNSPECIFIED | orcid.org/0000-0002-7301-8362 | UNSPECIFIED | Visalli, Elisa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benenati, Alessia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Amato, Giorgio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ancuta, Codrina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chirieac, Rodica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Villiger, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Adler, Sabine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dan, Diana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de la Pena Lefebvre, Paloma Garcia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rodriguez Rubio, Silvia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Valero Exposito, Marta | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sibilia, Jean | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chatelus, Emmanuel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gottenberg, Jacques Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chifflot, Helene | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Litinsky, Ira | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Del Galdo, Francesco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Venalis, Algirdas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Saketkoo, Lesley Ann | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lasky, Joseph A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kerzberg, Eduardo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Montoya, Fabiana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cosentino, Vanesa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Limonta, Massimiliano | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brucato, Antonio Luca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lupi, Elide | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Spertini, Francois | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ribi, Camillo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buss, Guillaume | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martin, Thierry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guffroy, Aurelien | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Poindron, Vincent | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chung, Lori | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmeiser, Tim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zebryk, Pawel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Riso, Nuno | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Riemekasten, Gabriela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rezus, Elena | UNSPECIFIED | orcid.org/0000-0002-8175-2583 | UNSPECIFIED | Puttini, Piercarlo Sarzi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-149095 |
DOI: |
10.1136/annrheumdis-2018-213455 |
Journal or Publication Title: |
Ann. Rheum. Dis. |
Volume: |
78 |
Number: |
5 |
Page Range: |
S. 648 - 657 |
Date: |
2019 |
Publisher: |
BMJ PUBLISHING GROUP |
Place of Publication: |
LONDON |
ISSN: |
1468-2060 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
THICKNESS SCORE; PROGNOSTIC-FACTORS; PREDICTION; INVOLVEMENT; MORTALITY; DEATH; VARIABILITY; IMPROVEMENT; VALIDATION | Multiple languages | Rheumatology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/14909 |
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