Nettersheim, Felix Sebastian, Loehrer, Philipp Alexander, Weber, Immo ORCID: 0000-0003-2979-234X, Jung, Fabienne, Dembelt, Till Anselm, Pelzer, Esther Annegret, Dafsari, Haidar Salimi, Huber, Carlo Andreas, Tittgemeyer, Marc and Timmermann, Lars (2019). Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease. Neuroimage, 190. S. 118 - 133. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Bimanual coordination is impaired in Parkinson's disease (PD), affecting patients' quality of life. Besides dysfunction of the basal ganglia network, alterations of cortical oscillatory coupling, particularly between prefrontal and (pre-)motoric areas, are thought to underlie this impairment. Here, we studied 16 PD patients OFF and ON medication and age-matched healthy controls recording high-resolution electroencephalography (EEG) during performance of spatially coupled and uncoupled bimanual finger movements. Dynamic causal modeling (DCM) for induced responses was used to infer task-induced effective connectivity within a network comprising bilateral prefrontal cortex (PFC), lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1). Performing spatially coupled movements, excitatory left-hemispheric PFC to lPM coupling was significantly stronger in controls compared to unmedicated PD patients. Levodopa-induced enhancement of this connection correlated with increased movement accuracy. During performance of spatially uncoupled movements, PD patients OFF medication exhibited inhibitory connectivity from left PFC to SMA. Levodopa intake diminished these inhibitory influences and restored excitatory PFC to lPM coupling. This restoration, however, did not improve motor function. Concluding, our results indicate that lateralization of prefrontal to premotor connectivity in PD can be augmented by levodopa substitution and is of compensatory nature up to a certain extent of complexity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Nettersheim, Felix SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loehrer, Philipp AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, ImmoUNSPECIFIEDorcid.org/0000-0003-2979-234XUNSPECIFIED
Jung, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dembelt, Till AnselmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelzer, Esther AnnegretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar SalimiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huber, Carlo AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittgemeyer, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-150694
DOI: 10.1016/j.neuroimage.2018.04.030
Journal or Publication Title: Neuroimage
Volume: 190
Page Range: S. 118 - 133
Date: 2019
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication: SAN DIEGO
ISSN: 1095-9572
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CEREBRAL-BLOOD-FLOW; SUBTHALAMIC NUCLEUS; OSCILLATORY ACTIVITY; CORTEX; COORDINATION; AMPLITUDE; SPEED; SYNCHRONIZATION; MODULATION; MODELMultiple languages
Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15069

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