John, Uwe ORCID: 0000-0002-1297-4086, Lu, Yameng ORCID: 0000-0001-9682-4407, Wohlrab, Sylke ORCID: 0000-0003-3190-0880, Groth, Marco ORCID: 0000-0002-9199-8990, Janouskovec, Jan ORCID: 0000-0001-6547-749X, Kohli, Gurjeet S., Mark, Felix C., Bickmeyer, Ulf ORCID: 0000-0002-5351-2902, Farhat, Sarah ORCID: 0000-0001-7725-2589, Felder, Marius, Frickenhaus, Stephan, Guillou, Laure, Keeling, Patrick J., Moustafa, Ahmed ORCID: 0000-0002-0111-3555, Porcel, Betina M., Valentin, Klaus and Gloeckner, Gernot (2019). An aerobic eukaryotic parasite with functional mitochondria that likely lacks a mitochondrial genome. Sci. Adv., 5 (4). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

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Abstract

Dinoflagellates are microbial eukaryotes that have exceptionally large nuclear genomes; however, their organelle genomes are small and fragmented and contain fewer genes than those of other eukaryotes. The genus Amoebophrya (Syndiniales) comprises endoparasites with high genetic diversity that can infect other dinoflagellates, such as those forming harmful algal blooms (e.g., Alexandrium). We sequenced the genome (similar to 100 Mb) of Amoebophrya ceratii to investigate the early evolution of genomic characters in dinoflagellates. The A. ceratii genome encodes almost all essential biosynthetic pathways for self-sustaining cellular metabolism, suggesting a limited dependency on its host. Although dinoflagellates are thought to have descended from a photosynthetic ancestor, A. ceratii appears to have completely lost its plastid and nearly all genes of plastid origin. Functional mitochondria persist in all life stages of A. ceratii, but we found no evidence for the presence of a mitochondrial genome. Instead, all mitochondrial proteins appear to be lost or encoded in the A. ceratii nucleus.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
John, UweUNSPECIFIEDorcid.org/0000-0002-1297-4086UNSPECIFIED
Lu, YamengUNSPECIFIEDorcid.org/0000-0001-9682-4407UNSPECIFIED
Wohlrab, SylkeUNSPECIFIEDorcid.org/0000-0003-3190-0880UNSPECIFIED
Groth, MarcoUNSPECIFIEDorcid.org/0000-0002-9199-8990UNSPECIFIED
Janouskovec, JanUNSPECIFIEDorcid.org/0000-0001-6547-749XUNSPECIFIED
Kohli, Gurjeet S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mark, Felix C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickmeyer, UlfUNSPECIFIEDorcid.org/0000-0002-5351-2902UNSPECIFIED
Farhat, SarahUNSPECIFIEDorcid.org/0000-0001-7725-2589UNSPECIFIED
Felder, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frickenhaus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guillou, LaureUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keeling, Patrick J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moustafa, AhmedUNSPECIFIEDorcid.org/0000-0002-0111-3555UNSPECIFIED
Porcel, Betina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valentin, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gloeckner, GernotUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-151573
DOI: 10.1126/sciadv.aav1110
Journal or Publication Title: Sci. Adv.
Volume: 5
Number: 4
Date: 2019
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 2375-2548
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SHIKIMATE PATHWAY; DINOFLAGELLATE; DIVERSITY; EVOLUTION; GENES; APICOMPLEXANMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15157

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